Zhang Yi, Shi Mengke, Yan Zhangren, Zhang Shao, Wang Mengya, Xu Han, Li Hongyu, Ying Yuchen, Qiu Shihong, Liu Jialei, Yang Hong, Chen Huabing, He Hui, Guo Zhengqing
State Key Laboratory of Radiation Medicine and Protection, Jiangsu Key Laboratory of Neuropsychiatric Diseases, and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.
State Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions and School of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China.
Adv Healthc Mater. 2020 Oct;9(20):e2001042. doi: 10.1002/adhm.202001042. Epub 2020 Sep 16.
Near-infrared (NIR) light-responsive nanoparticles (NPs) of organic photosensitizers (PS) hold great promise as phototherapeutic agents for precision photoinduced cancer therapy. However, highly photostable PS nanoparticles with extraordinary photoconversion capacities are urgently desired to fully realize potent phototherapy. Here, NIR nonlinear organic chromophore nanoparticles (NOC-NPs) are shown as single-component PS for dually cooperative phototherapy. Upon 785 nm irradiation, excited NOC-NPs pass through intrinsic intramolecular charge transfer (ICT) channel to generate both abundant singlet oxygen and local hyperthermia, affording synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) for tumor ablation. Furthermore, NOC-NPs exhibit dramatic photostability, enhanced cellular uptake, effective cytoplasmic translocation, as well as preferable tumor accumulation, further ensuring favorable in vivo singlet oxygen generation and hyperthermia for photoinduced tumor ablation. Thus, NOC-NPs may represent novel high-performance PS for synergistic photoinduced cancer therapy, providing new insights into the development of potent PS for clinical translation.
有机光敏剂（PS）的近红外（NIR）光响应纳米颗粒（NPs）作为用于精确光诱导癌症治疗的光治疗剂具有巨大潜力。然而，迫切需要具有非凡光转换能力的高光稳定性PS纳米颗粒，以充分实现有效的光治疗。在此，近红外非线性有机发色团纳米颗粒（NOC-NPs）被证明是用于双重协同光治疗的单组分PS。在785 nm照射下，受激的NOC-NPs通过固有的分子内电荷转移（ICT）通道产生大量单线态氧和局部热疗，为肿瘤消融提供协同光动力疗法（PDT）和光热疗法（PTT）。此外，NOC-NPs表现出显著的光稳定性、增强的细胞摄取、有效的细胞质转运以及良好的肿瘤积累，进一步确保了体内单线态氧的产生和热疗对光诱导肿瘤消融的有利作用。因此，NOC-NPs可能代表用于协同光诱导癌症治疗的新型高性能PS，为开发用于临床转化的有效PS提供了新的见解。
