College of Materials Science and Opto-Electronic Technology & Center of Materials Science and Optoelectronics Engineering & CAS Center for Excellence in Topological Quantum Computation & CAS Key Laboratory of Vacuum Physic , University of Chinese Academy of Sciences , Beijing 100049 , P. R. China.
Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety , Institute of High Energy Physics, Chinese Academy of Sciences , Beijing 100049 , People's Republic of China.
ACS Appl Mater Interfaces. 2019 May 15;11(19):17884-17893. doi: 10.1021/acsami.9b05196. Epub 2019 May 1.
Semiconducting polymer (SP) nanoparticles (NPs) have recently emerged as one of the most promising agents for photoacoustic imaging (PAI)-guided photothermal/photodynamic therapy (PTT/PDT). Herein, a triplet tellurophene-based SP (PNDI-2T) was synthesized with efficient tin-free direct heteroarylation polycondensation. The PNDI-2T NPs display remarkable near-infrared absorption and low cytotoxicity. In addition, PNDI-2T NPs can generate abundant reactive oxygen species (ROS) since tellurophene facilitates the intersystem crossing to generate triplet excited states. Remarkably, PNDI-2T NPs present a high photothermal conversion efficiency (η = 45%) and a high ROS yield (ΦΔ = 38.7%) under 808 nm laser irradiation. Furthermore, we showed that PNDI-2T NPs could be excellent PAI-guided PTT/PDT agents for cancer theranostics. This study provides a new route to developing highly efficient and low cytotoxic agents for PAI-guided PTT/PDT.
半导体聚合物 (SP) 纳米粒子 (NPs) 最近成为光声成像 (PAI) 引导光热/光动力治疗 (PTT/PDT) 最有前途的试剂之一。本文通过高效无锡直接杂芳族聚合缩聚合成了基于三联噻吩的 SP (PNDI-2T)。PNDI-2T NPs 具有显著的近红外吸收和低细胞毒性。此外，由于碲吩有利于系间穿越以产生三重态激发态，因此 PNDI-2T NPs 可以产生丰富的活性氧物种 (ROS)。值得注意的是，PNDI-2T NPs 在 808nm 激光照射下表现出高的光热转换效率 (η = 45%) 和高的 ROS 产率 (ΦΔ = 38.7%)。此外，我们表明 PNDI-2T NPs 可以作为癌症治疗的优异 PAI 引导 PTT/PDT 试剂。这项研究为开发用于 PAI 引导 PTT/PDT 的高效低细胞毒性试剂提供了新途径。
