氧化应激、宫内生长受限与 2 型糖尿病的发育编程
Oxidative Stress, Intrauterine Growth Restriction, and Developmental Programming of Type 2 Diabetes.
机构信息
Center for Research on Reproduction and Women's Health, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania.
出版信息
Physiology (Bethesda). 2018 Sep 1;33(5):348-359. doi: 10.1152/physiol.00023.2018.
Abstract
Intrauterine growth restriction (IUGR) leads to reduced birth weight and the development of metabolic diseases such as Type 2 diabetes in adulthood. Mitochondria dysfunction and oxidative stress are commonly found in key tissues (pancreatic islets, liver, and skeletal muscle) of IUGR individuals. In this review, we explore the role of oxidative stress in IUGR-associated diabetes etiology.
摘要
宫内生长受限（IUGR）会导致出生体重降低，并在成年后发展为代谢疾病，如 2 型糖尿病。在 IUGR 个体的关键组织（胰岛、肝脏和骨骼肌）中，普遍存在线粒体功能障碍和氧化应激。在这篇综述中，我们探讨了氧化应激在 IUGR 相关糖尿病发病机制中的作用。
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