Gee Jay E, Gulvik Christopher A, Elrod Mindy G, Batra Dhwani, Rowe Lori A, Sheth Mili, Hoffmaster Alex R
Emerg Infect Dis. 2017 Jul;23(7):1133-1138. doi: 10.3201/eid2307.161978.
The bacterium Burkholderia pseudomallei causes melioidosis, which is mainly associated with tropical areas. We analyzed single-nucleotide polymorphisms (SNPs) among genome sequences from isolates of B. pseudomallei that originated in the Western Hemisphere by comparing them with genome sequences of isolates that originated in the Eastern Hemisphere. Analysis indicated that isolates from the Western Hemisphere form a distinct clade, which supports the hypothesis that these isolates were derived from a constricted seeding event from Africa. Subclades have been resolved that are associated with specific regions within the Western Hemisphere and suggest that isolates might be correlated geographically with cases of melioidosis. One isolate associated with a former World War II prisoner of war was believed to represent illness 62 years after exposure in Southeast Asia. However, analysis suggested the isolate originated in Central or South America.
类鼻疽伯克霍尔德菌可引发类鼻疽，该病主要与热带地区相关。我们通过将西半球来源的类鼻疽伯克霍尔德菌分离株的基因组序列与东半球来源的分离株的基因组序列进行比较，分析了其中的单核苷酸多态性（SNP）。分析表明，西半球的分离株形成了一个独特的进化枝，这支持了这些分离株源自非洲的一次有限传播事件的假说。已分辨出与西半球特定区域相关的亚进化枝，这表明分离株在地理上可能与类鼻疽病例相关。一株与一名二战前战俘有关的分离株被认为代表了在东南亚接触病原体62年后出现的疾病。然而，分析表明该分离株起源于中美洲或南美洲。
