Franquet-Griell Helena, Gómez-Canela Cristian, Ventura Francesc, Lacorte Silvia
Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona18- 26, 08034 Barcelona, Catalonia, Spain.
Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona18- 26, 08034 Barcelona, Catalonia, Spain.
Environ Pollut. 2017 Oct;229:505-515. doi: 10.1016/j.envpol.2017.06.011. Epub 2017 Jun 16.
This study presents the occurrence and impact of 78 anticancer drugs in Spanish river basins based on consumption data in pharmacies during the period 2010-2015 and calculation of the predicted environmental concentrations (PEC). The total consumption of anticancer drugs in Spanish pharmacies was of 23.4 tons in 2015, being mycophenolic acid and hydroxycarbamide the drugs with the highest prescription. Their PECs in river at national scale were up to 80 ng/L. However, the use of different dilution factors revealed major differences between hydrographic basins, and PEC rose up to 68,014 ng/L in highly populated rivers with low flows. Concerning acute toxicity, there was no expected risk for the aquatic environment. However, chronic toxicity tests revealed possible long-term mutagenic effects for aquatic organisms. This study provides the tools for the estimation of PEC at river basin scale using time trend consumption data compilation. This information is very useful for prioritization of compounds of concern and permit to focus resources in environmental monitoring and risk evaluation.
本研究基于2010 - 2015年期间西班牙药店的消费数据以及预测环境浓度（PEC）的计算，介绍了78种抗癌药物在西班牙流域的出现情况及其影响。2015年西班牙药店抗癌药物的总消费量为23.4吨，其中霉酚酸和羟基脲是处方量最高的药物。它们在全国范围内河流中的PEC高达80纳克/升。然而，使用不同的稀释因子显示出不同水文流域之间存在重大差异，在人口密集、流量低的河流中PEC升至68,014纳克/升。关于急性毒性，对水生环境没有预期风险。然而，慢性毒性测试显示对水生生物可能存在长期诱变作用。本研究提供了利用时间趋势消费数据汇编来估算流域尺度PEC的工具。这些信息对于确定关注化合物的优先级非常有用，并有助于将资源集中用于环境监测和风险评估。
