McKinnon Emilie T, Fridriksson Julius, Glenn G Russell, Jensen Jens H, Helpern Joseph A, Basilakos Alexandra, Rorden Chris, Shih Andy Y, Spampinato M Vittoria, Bonilha Leonardo
Department of Neurology, Medical University of South Carolina, Charleston, SC.
Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC.
Ann Neurol. 2017 Jul;82(1):147-151. doi: 10.1002/ana.24983.
Restrengthening of the residual language network is likely to be crucial for speech recovery in poststroke aphasia. Eight participants with chronic aphasia received intensive speech therapy for 3 weeks, with standardized naming tests and brain magnetic resonance imaging before and after therapy. Kurtosis-based diffusion tensor tractography was used to measure mean kurtosis (MK) along a segment of the inferior longitudinal fasciculus (ILF). Therapy-related reduction in the number of semantic but not phonemic errors was associated with strengthening (renormalization) of ILF MK (r = -0.90, p < 0.05 corrected), suggesting that speech recovery is related to structural plasticity of language-specific components of the residual language network. Ann Neurol 2017;82:147-151.
残余语言网络的重新强化可能是中风后失语症患者言语恢复的关键。八名慢性失语症患者接受了为期3周的强化言语治疗，并在治疗前后进行了标准化命名测试和脑磁共振成像。基于峰度的扩散张量纤维束成像用于测量沿下纵束（ILF）一段的平均峰度（MK）。与治疗相关的语义错误而非音素错误数量的减少与ILF的MK强化（重新归一化）相关（r = -0.90，校正后p < 0.05），这表明言语恢复与残余语言网络中特定语言成分的结构可塑性有关。《神经病学纪事》2017年；82:147 - 151。
