Xiang Yiming, Li Jun, Liu Xiangmei, Cui Zhenduo, Yang Xianjin, Yeung K W K, Pan Haobo, Wu Shuilin
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science & Engineering, Hubei University, Wuhan 430062, China.
School of Materials Science & Engineering, Tianjin University, Tianjin 300072, China.
Mater Sci Eng C Mater Biol Appl. 2017 Oct 1;79:629-637. doi: 10.1016/j.msec.2017.05.115. Epub 2017 May 17.
Poly(lactic-co-glycolic acid)/Ag/ZnO nanorods coating were successfully prepared on the surface of Ti metallic implants using a hydrothermal method and subsequent spin-coating of mixtures of poly(lactic-co-glycolic acid) and silver nanoparticles. The poly(lactic-co-glycolic acid)/Ag/ZnO nanorods coating exhibited excellent antibacterial efficacy of over 96% against both Staphylococcus aureus and Escherichia coli when the initial content of Ag nanoparticles was over 3wt%. In addition, the release of both silver and zinc could last for over a hundred days due to the enwrapping of poly(lactic-co-glycolic acid). Proliferation of mouse calvarial cells exhibited minimal cytotoxicity on the poly(lactic-co-glycolic acid)/Ag/ZnO coating with an initial content of Ag nanoparticles of 1wt% and 3wt%, while it inhibited cell proliferation once this value was increased to 6wt%. The results revealed that this poly(lactic-co-glycolic acid)/Ag/ZnO composite could provide a long-lasting antibacterial approach and good cytocompatibility, thus exhibiting considerable potential for biomedical application in orthopedic and dental implants with excellent self-antibacterial activity and good biocompatibility.
采用水热法并随后旋涂聚乳酸 - 乙醇酸共聚物（PLGA）和银纳米颗粒的混合物，在钛金属植入物表面成功制备了聚乳酸 - 乙醇酸共聚物/银/氧化锌纳米棒涂层。当初始银纳米颗粒含量超过3wt%时，聚乳酸 - 乙醇酸共聚物/银/氧化锌纳米棒涂层对金黄色葡萄球菌和大肠杆菌均表现出超过96%的优异抗菌效果。此外，由于聚乳酸 - 乙醇酸共聚物的包裹作用，银和锌的释放可持续一百多天。对于初始银纳米颗粒含量为1wt%和3wt%的聚乳酸 - 乙醇酸共聚物/银/氧化锌涂层，小鼠颅骨细胞的增殖表现出最小的细胞毒性，而当该值增加到6wt%时，它会抑制细胞增殖。结果表明，这种聚乳酸 - 乙醇酸共聚物/银/氧化锌复合材料可以提供持久的抗菌方法和良好的细胞相容性，因此在具有优异自抗菌活性和良好生物相容性的骨科和牙科植入物的生物医学应用中具有相当大的潜力。
