将甲氨蝶呤和环磷酰胺包封在多壁碳纳米管上的聚丙烯酸和聚乙二醇形成的聚合物复合物中，作为药物传递系统。
Encapsulation of methotrexate and cyclophosphamide in interpolymer complexes formed between poly acrylic acid and poly ethylene glycol on multi-walled carbon nanotubes as drug delivery systems.
机构信息
Applied Chemistry Department, Faculty of Petroleum and Gas (Gachsaran), Yasouj University, Gachsaran 75813-56001, Iran.
Chemistry Department, Faculty of Science, Imam Khomeini International University, P.O. Box 288 Qazvin 34149, Iran.
出版信息
Mater Sci Eng C Mater Biol Appl. 2017 Oct 1;79:841-847. doi: 10.1016/j.msec.2017.05.089. Epub 2017 May 14.
By combining the advantage of multi-walled carbon nanotubes (MWCNTs) and interpolymer complexes, we synthesis a new carrier system consist of poly(acrylic acid)/poly(ethylene glycol)/carbon nanotube (PAA/PEG/CNT). Then, Methotrexate (MTX) and Cyclophosphamide (CPP) were loaded on PAA/PEG/CNT, and the physicochemical properties of nanoparticles characterized by Infrared spectroscopy (IR), Scanning Electron Microscopy (SEM), Thermo Gravimetric Analysis (TGA) and Nuclear Magnetic Resonance (NMR). In the second part after efficiency determination of loaded drugs, in vitro drug release study was examined with ultra violet spectroscopy (UV) in pH=7.4 buffer (human body range) and pH=4 buffer (pH of cancer cells), and fever temperature drug release kinetic was studied by different mathematical models.
通过结合多壁碳纳米管（MWCNTs）和聚合物间复合物的优势，我们合成了一种由聚（丙烯酸）/聚（乙二醇）/碳纳米管（PAA/PEG/CNT）组成的新型载体系统。然后，将甲氨蝶呤（MTX）和环磷酰胺（CPP）负载到 PAA/PEG/CNT 上，并通过红外光谱（IR）、扫描电子显微镜（SEM）、热重分析（TGA）和核磁共振（NMR）对纳米粒子的物理化学性质进行了表征。在确定载药效率的第二部分之后，通过紫外光谱（UV）在 pH=7.4 缓冲液（人体范围）和 pH=4 缓冲液（癌细胞 pH 值）中进行了体外药物释放研究，并通过不同的数学模型研究了发热温度药物释放动力学。
Zotero 插件