School of Biosciences and Technology, VIT University, Vellore 632014, Tamil Nadu, India.
Centre for Biomaterials, Cellular and Molecular Theranostics, VIT University, Vellore 632014, Tamil Nadu, India.
Mater Sci Eng C Mater Biol Appl. 2017 Oct 1;79:950-957. doi: 10.1016/j.msec.2017.05.121. Epub 2017 May 17.
The major purpose of cardiac tissue engineering is to engineer cells on scaffolds and use it as a substitute to infarcted cardiac cells. With an ever-increasing risk of cardiac diseases there is an increasing need to have a stable and sustainable approach to cure such ailments. This review provides a comprehensive update on the cell sources and biomaterials essential for cardiac tissue engineering, ensuring their biocompatibility under a variety of conditions. Cells can be obtained from allogenic or autologous sources. The cells sources described in this paper are cardiomyocytes, a variety of stem cells, fibroblasts and parthenogenetic cells. Scaffolds to seed the cells should fulfill various criteria, the most important ones being non-immunogenicity, biodegradability and native tissue mimicking. There are several kinds of scaffolds including hydrogels, prefabricated matrices, decellularized scaffolds and cell sheets. Using this knowledge of cell sources and scaffold fabrication, production of various tissue engineered products is possible.
心脏组织工程的主要目的是在支架上构建细胞，并将其用作梗死心脏细胞的替代品。由于心脏病的风险不断增加，因此需要有一种稳定且可持续的方法来治疗这种疾病。本综述提供了对心脏组织工程中细胞来源和生物材料的全面更新，确保了它们在各种条件下的生物相容性。细胞可以从同种异体或自体来源获得。本文中描述的细胞来源包括心肌细胞、各种干细胞、成纤维细胞和孤雌生殖细胞。用于接种细胞的支架应满足各种标准，最重要的标准是非免疫原性、可生物降解性和类似天然组织。有几种支架，包括水凝胶、预制基质、脱细胞支架和细胞片。利用这些对细胞来源和支架制造的了解，可以生产出各种组织工程产品。
