生物材料及其与组织工程相关技术的主要用途更新。

Update on the main use of biomaterials and techniques associated with tissue engineering.

机构信息

Hematology and Stem Cell Laboratory, Faculty of Pharmacy, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, Brazil; Post Graduate Program in Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre 90010-170, Brazil.

出版信息

Drug Discov Today. 2018 Aug;23(8):1474-1488. doi: 10.1016/j.drudis.2018.03.013. Epub 2018 Mar 30.

DOI:10.1016/j.drudis.2018.03.013

PMID:29608960

Abstract

Regenerative medicine involves the study of cells, signaling cues and biomatrices to restore normal function of tissues and organs. To develop the matrices for use in tissue engineering there are three main groups of biomaterials: (i) naturally derived materials; (ii) synthetic polymers; and (iii) decellularized organ or tissue scaffolds. These biomaterials, in various forms such as hydrogels, nanofibers and 3D scaffolds, among others, have been employed for different tissue regeneration purposes, with several techniques involved in their production, including rapid prototyping, tissue decellularization and electrospinning. In this review, the main topics of hydrogels, 3D printing and electrospun scaffolds, other biomaterials and decellularization and recellularization will be discussed.

摘要

再生医学涉及细胞、信号分子和生物基质的研究，以恢复组织和器官的正常功能。为了开发用于组织工程的基质，有三类主要的生物材料：（i）天然衍生材料；（ii）合成聚合物；和（iii）脱细胞化的器官或组织支架。这些生物材料，以各种形式，如水凝胶、纳米纤维和 3D 支架等，已经被用于不同的组织再生目的，其生产涉及多种技术，包括快速成型、组织脱细胞化和静电纺丝。在这篇综述中，将讨论水凝胶、3D 打印和静电纺丝支架、其他生物材料以及脱细胞化和再细胞化的主要主题。