Umano Giuseppina Rosaria, Martino Mariangela, Santoro Nicola
Department of Pediatrics, Yale University, 06520, New Haven, CT, USA.
Dipartimento della Donna, del Bambino, di Vhirurgia Generale e Specialistica, Universita' della Campania Luigi Vanvitelli, 80138, Napoli, Italy.
Children (Basel). 2017 Jun 18;4(6):49. doi: 10.3390/children4060049.
Non-alcoholic fatty liver disease (NAFLD) is one of the most common complications of obesity. Several studies have shown that genetic predisposition probably plays an important role in its pathogenesis. In fact, in the last few years a large number of genetic studies have provided compelling evidence that some gene variants, especially those in genes encoding proteins regulating lipid metabolism, are associated with intra-hepatic fat accumulation. Here we provide a comprehensive review of the gene variants that have affected the natural history of the disease.
非酒精性脂肪性肝病（NAFLD）是肥胖最常见的并发症之一。多项研究表明，遗传易感性可能在其发病机制中起重要作用。事实上，在过去几年中，大量的基因研究提供了令人信服的证据，表明一些基因变异，尤其是那些编码调节脂质代谢蛋白质的基因变异，与肝内脂肪堆积有关。在此，我们对影响该疾病自然史的基因变异进行全面综述。
