Srivedavyasasri Radhakrishnan, Hayes Taylor, Ross Samir A
a National Center for Natural Product Research , University of Mississippi , University , MS , USA.
b Departmant of BioMolecular Sciences, School of Pharmacy , University of Mississippi , University , MS , USA.
Nat Prod Res. 2017 Sep;31(17):2058-2061. doi: 10.1080/14786419.2016.1269096. Epub 2016 Dec 27.
Salvia apiana (white sage, Lamiaceae family) plant is native to southern California and parts of Mexico. Some Native American tribes local to this region consider S. apiana to be sacred and burn the leaves as incense for purification ceremonies. The plant has been used to treat sore throats, coughs, chest colds, upper respiratory infections and poison oak rashes. The aqueous ethanolic extract of S. apiana showed moderate CB1 activity (58.3% displacement). Chromatographic purification of the ethanolic extract on silica gel column led to isolation of nine compounds: rosmadial (I), carnosol (II), 16-hydroxycarnosol (III), sageone (IV), cirsimaritin (V), salvigenin (VI), oleanolic acid (VII), 3β,28-dihydroxy-urs-12-ene (VIII), and ursolic acid (IX). The structures of the isolated compounds were determined by their 1D, 2D NMR and MS spectral data. All the fractions and isolated compounds were tested for cannabinoid and opioid receptor binding.
白鼠尾草（Salvia apiana，唇形科）原产于南加州和墨西哥部分地区。该地区的一些美洲原住民部落认为白鼠尾草是神圣的，并燃烧其叶子作为净化仪式的熏香。这种植物已被用于治疗喉咙痛、咳嗽、风寒、上呼吸道感染和毒橡树皮疹。白鼠尾草的乙醇水提取物显示出适度的CB1活性（58.3%置换率）。乙醇提取物在硅胶柱上进行色谱纯化，分离出九种化合物：迷迭香二醛（I）、鼠尾草酸（II）、16-羟基鼠尾草酸（III）、鼠尾草酮（IV）、蓟黄素（V）、5-羟基-7,8,2'-三甲氧基黄酮（VI）、齐墩果酸（VII）、3β,28-二羟基乌苏-12-烯（VIII）和熊果酸（IX）。通过一维、二维核磁共振和质谱光谱数据确定了分离出的化合物的结构。对所有馏分和分离出的化合物进行了大麻素和阿片受体结合测试。
