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本文引用的文献

1
Use of TNF-inhibitors and ustekinumab for psoriasis during pregnancy: A patient series.妊娠期间使用肿瘤坏死因子抑制剂和优特克单抗治疗银屑病：病例系列
Dermatol Ther. 2017 May;30(3). doi: 10.1111/dth.12454. Epub 2017 Jan 10.
2
Ustekinumab therapy for Crohn's disease during pregnancy: a case report and review of the literature.妊娠期间使用优特克单抗治疗克罗恩病：一例病例报告及文献综述
J Clin Pharm Ther. 2017 Apr;42(2):234-236. doi: 10.1111/jcpt.12492. Epub 2016 Dec 22.
3
Ustekinumab for the Treatment of Refractory Crohn's Disease: The Spanish Experience in a Large Multicentre Open-label Cohort.乌司奴单抗治疗难治性克罗恩病：西班牙在大型多中心开放标签队列中的经验
Inflamm Bowel Dis. 2016 Jul;22(7):1662-9. doi: 10.1097/MIB.0000000000000842.
4
Successful pregnancy outcome under prolonged ustekinumab treatment in a patient with Crohn's disease and paradoxical psoriasis.一名克罗恩病合并矛盾性银屑病患者在接受长期优特克单抗治疗后成功获得妊娠结局
J Eur Acad Dermatol Venereol. 2016 Dec;30(12):e191-e192. doi: 10.1111/jdv.13499. Epub 2015 Nov 11.
5
Subcutaneous Ustekinumab Provides Clinical Benefit for Two-Thirds of Patients With Crohn's Disease Refractory to Anti-Tumor Necrosis Factor Agents.皮下注射乌司奴单抗可为三分之二对肿瘤坏死因子拮抗剂治疗抵抗的克罗恩病患者带来临床获益。
Clin Gastroenterol Hepatol. 2016 Feb;14(2):242-50.e1-2. doi: 10.1016/j.cgh.2015.09.018. Epub 2015 Sep 30.
6
Anti-IL-12/23p40 antibodies for induction of remission in Crohn's disease.用于诱导克罗恩病缓解的抗IL-12/23 p40抗体。
Cochrane Database Syst Rev. 2015 May 5(5):CD007572. doi: 10.1002/14651858.CD007572.pub2.
7
Pregnancy during Ustekinumab Treatment for Severe Psoriasis.使用优特克单抗治疗重度银屑病期间怀孕
Dermatology. 2015;231(2):103-4. doi: 10.1159/000380880. Epub 2015 Mar 17.
8
Inadvertent pregnancy during ustekinumab therapy in a patient with plaque psoriasis and impetigo herpetiformis.一名患有斑块状银屑病和疱疹样脓疱病的患者在接受乌司奴单抗治疗期间意外怀孕。
J Eur Acad Dermatol Venereol. 2016 Mar;30(3):488-90. doi: 10.1111/jdv.12872. Epub 2014 Nov 21.
9
Pregnancy outcomes of two patients exposed to ustekinumab in the first trimester.两名在孕早期接触乌司奴单抗的患者的妊娠结局。
Australas J Dermatol. 2014 Aug;55(3):235-6. doi: 10.1111/ajd.12214.
10
Subcutaneous ustekinumab for the treatment of anti-TNF resistant Crohn's disease--the McGill experience.皮下注射优特克单抗治疗抗TNF耐药性克罗恩病——麦吉尔大学的经验
J Crohns Colitis. 2014 Nov;8(11):1516-22. doi: 10.1016/j.crohns.2014.06.005. Epub 2014 Jul 1.

接受优特克单抗治疗的克罗恩病患者发生宫内胎儿死亡和流产：病例报告及文献综述

Fetal death in utero and miscarriage in a patient with Crohn's disease under therapy with ustekinumab: case-report and review of the literature.

作者信息

Venturin C, Nancey S, Danion P, Uzzan M, Chauvenet M, Bergoin C, Roblin X, Flourié B, Boschetti G

机构信息

Department of Gastroenterology, Lyon-Sud hospital, Hospices Civils de Lyon, Université Lyon1, Lyon, France.

INSERM U1111, Centre International de Recherche en Infectiologie, Lyon, France.

出版信息

BMC Gastroenterol. 2017 Jun 19;17(1):80. doi: 10.1186/s12876-017-0633-6.

DOI:10.1186/s12876-017-0633-6
PMID:28629323
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5477379/
Abstract

BACKGROUND

Ustekinumab is a fully human monoclonal antibody against the p40 subunit of interleukin (IL) 12 and 23 which is involved in the pathogenesis of several inflammatory diseases. Ustekinumab is approved for psoriasis and psoriatic arthritis treatment and has been successfully evaluated in phase II and III trials for patients with Crohn's disease (CD).

CASE PRESENTATION

We report here the case of a patient who became pregnant during treatment with ustekinumab for a refractory CD and which ended in miscarriage.

CONCLUSION

Ustekinumab is a relatively new pharmacotherapy and in addition to this clinical case, we reviewed the published literature concerning the use of this treatment during pregnancy and its consequences on pregnancy and fetus outcome.

摘要

背景

优特克单抗是一种全人源单克隆抗体，可作用于参与多种炎症性疾病发病机制的白细胞介素（IL）12和23的p40亚基。优特克单抗已被批准用于治疗银屑病和银屑病关节炎，并已在克罗恩病（CD）患者的II期和III期试验中得到成功评估。

病例报告

我们在此报告一例患者，该患者在使用优特克单抗治疗难治性CD期间怀孕，最终流产。

结论

优特克单抗是一种相对较新的药物疗法，除了本临床病例外，我们还回顾了已发表的有关该治疗在孕期的使用及其对妊娠和胎儿结局影响的文献。