Keller Claudia, Liesegang Annette, Frey Diana, Wichert Brigitta
Institute of Animal Nutrition, University of Zurich, Winterthurerstr, 270, CH-8057, Zurich, Switzerland.
Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland.
BMC Vet Res. 2017 Jun 19;13(1):184. doi: 10.1186/s12917-017-1107-3.
The existence of a genetic predisposition to obesity is commonly recognized in humans and rodents. Recently, a link between genetics and overweight was shown in cats. The goal of this study was to identify the effect of diet composition on plasma levels of glucose, insulin, free fatty acids and triglycerides in cats receiving different diets (high-carbohydrate, high-fat and high-protein diets).
Insulin and leptin concentrations were significantly correlated with phenotype. Insulin levels were lower, whereas leptin levels were higher in cats predisposed to overweight. The other blood parameters were not correlated with phenotype. Intake of the high-carbohydrate diet resulted in higher insulin concentrations compared with the two other diets. Insulin levels were within the values described for non-obese cats in previous studies.
There was no difference in metabolic response between the two groups. As the high-carbohydrate diet led to the highest insulin blood concentrations, it might be useful to avoid such diets in cats predisposed to overweight. In addition, even cats with genetically linked obesity can regain insulin sensitivity after weight loss.
人类和啮齿动物中普遍认为存在肥胖的遗传易感性。最近，在猫身上也发现了遗传与超重之间的联系。本研究的目的是确定饮食组成对接受不同饮食（高碳水化合物、高脂肪和高蛋白饮食）的猫的血浆葡萄糖、胰岛素、游离脂肪酸和甘油三酯水平的影响。
胰岛素和瘦素浓度与表型显著相关。易超重的猫胰岛素水平较低，而瘦素水平较高。其他血液参数与表型无关。与其他两种饮食相比，高碳水化合物饮食的摄入导致胰岛素浓度更高。胰岛素水平在前述非肥胖猫的研究范围内。
两组之间的代谢反应没有差异。由于高碳水化合物饮食导致最高的胰岛素血浓度，对于易超重的猫避免此类饮食可能是有益的。此外，即使是与遗传相关的肥胖猫在减肥后也能恢复胰岛素敏感性。
