独特的甲型流感交叉反应性记忆 CD8 T 细胞受体库具有预防 EBV 血清转化的潜力。
Unique influenza A cross-reactive memory CD8 T-cell receptor repertoire has a potential to protect against EBV seroconversion.
机构信息
Department of Pathology, University of Massachusetts Medical School, Worcester, Mass; Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, Mass.
Department of Pathology, University of Massachusetts Medical School, Worcester, Mass.
出版信息
J Allergy Clin Immunol. 2017 Oct;140(4):1206-1210. doi: 10.1016/j.jaci.2017.05.037. Epub 2017 Jun 16.
Abstract
Detection of unique, functionally influenza A/EBV crossreactive oligoclonal CD8 T-cell repertoires in rare individuals who remain EBV-seronegative into fourth decade of life suggests that T-cell crossreactivity dependent heterologous immunity may protect from EBV infection.
摘要
在罕见的个体中，这些个体在生命的第四个十年仍然保持 EBV 血清阴性，检测到独特的、具有功能性的流感 A/EBV 交叉反应性寡克隆 CD8 T 细胞库，这表明 T 细胞交叉反应性依赖的异源免疫可能有助于预防 EBV 感染。
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