Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.
National Heart and Lung Institute, Imperial College London, London, UK.
J Physiol. 2020 Jul;598(14):2995-3003. doi: 10.1113/JP278131. Epub 2019 Jul 26.
Molecular mechanisms underlying heart failure (HF) are only partly understood. Non-coding RNAs (ncRNAs) have been reported to control function and signalling routes in the myocardium. As ncRNAs such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs) or circular RNAs (circRNAs) can be selectively targeted via pharmacological approaches, this opens new avenues for diagnostic and therapeutic approaches. Here, we review the main ncRNA classes and how they influence cardiac biology. In addition we provide insight into the role of ncRNAs in chemotherapy-induced cardiac dysfunction. To provide a better understanding of ncRNAs in cardiovascular biology we present an outlook on specialized functions such as chromatin remodelling, biomarker potential and the recently discovered ncRNA-derived micropeptides.
心力衰竭（HF）的潜在分子机制尚未完全阐明。非编码 RNA（ncRNA）已被报道可控制心肌的功能和信号通路。由于可以通过药理学方法选择性地靶向 ncRNA 如 microRNAs（miRNAs）、长非编码 RNA（lncRNA）或环状 RNA（circRNA），这为诊断和治疗方法开辟了新途径。在这里，我们综述了主要的 ncRNA 类别以及它们如何影响心脏生物学。此外，我们还探讨了 ncRNA 在化疗诱导的心脏功能障碍中的作用。为了更好地理解心血管生物学中的 ncRNA，我们介绍了它们在染色质重塑、生物标志物潜力以及最近发现的 ncRNA 衍生的微肽等方面的特殊功能。
