Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, New York 10065.
Laboratory of Humoral Response to Pathogens, Institut Pasteur, Paris 75015, France.
Cold Spring Harb Perspect Biol. 2018 May 1;10(5):a029389. doi: 10.1101/cshperspect.a029389.
Most broadly neutralizing antibodies to HIV-1 have in common an extreme degree of somatic hypermutation (SHM), which correlates with their ability to neutralize multiple viral strains. However, achieving such extreme SHM by immunization remains a challenge. Here, we discuss how antigenic variation during HIV-1 infection may work to exacerbate SHM by permitting multiple iterative cycles of affinity maturation in germinal centers, and speculate on how this could be recapitulated through vaccination.
大多数广谱中和抗体对 HIV-1 具有一个共同点，那就是极高程度的体细胞超突变（SHM），这与其中和多种病毒株的能力相关。然而，通过免疫接种实现这种极端的 SHM 仍然是一个挑战。在这里，我们讨论了 HIV-1 感染期间的抗原变异如何通过允许生发中心中的多次亲和力成熟迭代循环来加剧 SHM，并推测了如何通过疫苗接种来重现这一过程。
