Tang Li, Pan Xiong-Fei, Lee Andy H, Binns Colin W, Yang Chun-Xia, Sun Xin
Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu, China.
Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
BMJ Open. 2017 Jun 19;7(6):e014874. doi: 10.1136/bmjopen-2016-014874.
Improving the health and nutrition of women and children is a priority for Western China, where the economy is less developed. Due to the dynamic nature of lifestyle, modern food habits and nutrition, there is a need to update our limited knowledge and understanding of maternal lifestyle and nutritional status and their impact on pregnancy and infant health outcomes. While breast milk is the preferred feeding option, infant formula use is widespread in China. It is thus necessary to examine the effects of formula consumption on growth and morbidity.
This is an ongoing prospective cohort study started in 2015 in Chengdu, Sichuan Province. A sample of 1901 pregnant women at 15-20 weeks of gestation were recruited from four maternal and child health hospitals and are followed prospectively to 12 months post partum. Detailed information on maternal lifestyle and nutritional status, obstetric complications, pregnancy outcomes, infant feeding practices, illnesses of the mother and infant and growth trajectory is collected through personal interviews, anthropometric measures and medical records and local health management system records retrieval. Multilevel mixed regression models, adjusted for clustering, will be applied to investigate the association between various exposure variables of interest and the longitudinal outcomes, taking into account the correlated data structure and the nesting of observations. Kaplan-Meier test and Cox regression analysis will be used to analyse the time-to-event data.
Ethical approval has been obtained from the ethics committee of West China School of Public Health, Sichuan University and the Human Research Ethics Committee of Curtin University. Results will be presented at national and international conferences and published in peer-reviewed journals.
改善妇女和儿童的健康与营养状况是中国西部经济欠发达地区的一项优先任务。由于生活方式、现代饮食习惯和营养状况的动态变化，我们需要更新对孕产妇生活方式和营养状况及其对妊娠和婴儿健康结局影响的有限认识。虽然母乳喂养是首选的喂养方式，但婴儿配方奶粉在中国的使用也很普遍。因此，有必要研究配方奶粉消费对生长和发病率的影响。
这是一项正在进行的前瞻性队列研究，于2015年在四川省成都市启动。从四家妇幼保健院招募了1901名妊娠15至20周的孕妇样本，并对其进行前瞻性随访至产后12个月。通过个人访谈、人体测量和医疗记录以及当地卫生管理系统记录检索，收集有关孕产妇生活方式和营养状况、产科并发症、妊娠结局、婴儿喂养方式、母婴疾病以及生长轨迹的详细信息。将应用经过聚类调整的多水平混合回归模型，考虑相关数据结构和观察值的嵌套情况，研究各种感兴趣的暴露变量与纵向结局之间的关联。将使用Kaplan-Meier检验和Cox回归分析来分析事件发生时间数据。
已获得四川大学华西公共卫生学院伦理委员会和科廷大学人类研究伦理委员会的伦理批准。研究结果将在国内和国际会议上公布，并发表在同行评审期刊上。
