Nguyen Cong Luat, Nguyen Phung Thi Hoang, Chu Tan Khac, Ha Anh Vo Van, Pham Ngoc Minh, Duong Dat Van, Do Dung Van, Tang Hong Kim, Binns Colin W, Lee Andy H
National Expanded Program on Immunization, National Institute of Hygiene and Epidemiology, Ha Noi, Vietnam.
University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.
BMJ Open. 2017 Sep 5;7(9):e016794. doi: 10.1136/bmjopen-2017-016794.
To determine modifiable maternal risk factors for adverse pregnancy, postpartum maternal and child health outcomes in Vietnam.
This prospective cohort study included pregnant women seeking prenatal care at six hospitals in three large cities in Vietnam. After enrolment, eligible participants who gave their consent to participate in the study were interviewed at 24-28 weeks' gestation. Glucose testing was conducted and blood pressure was measured during this period. Each participant will be assessed prospectively during their postnatal visits at delivery, 1, 3, 6, 12, 18 and 24 months, and will be followed up for 5 years.
Of 2248 eligible pregnant women, 2030 were recruited (participation rate 90.3%) between August 2015 and July 2016. All participants completed the baseline assessment. Their mean (SD) age was 27.6 (5.3) years. The mean pre-pregnancy body mass index (BMI) was 20.2 (SD 2.6) kg/m, with nearly two-thirds of participants having a normal pre-pregnancy BMI (18.5 to <23.0 kg/m) and one-quarter being underweight (pre-pregnancy BMI <18.5 kg/m). Overweight or obese mothers (pre-pregnancy BMI ≥23.0 kg/m) accounted for 12.8%. No pregnant women reported smoking during their pregnancy while 13.4% of them had continued drinking. 22.8% of participants had hyperglycaemia. Their mean systolic blood pressure was 105.6 (SD 8.2) mm Hg, and diastolic blood pressure was 67.4 (SD 7.5) mm Hg.
The relationships of maternal lifestyle and nutritional status with the health outcomes of pregnancy, postpartum maternity and infants will be analysed. Meanwhile, participants will be closely tracked to minimise loss to follow-up.
确定越南不良妊娠、产后母婴健康结局的可改变孕产妇风险因素。
这项前瞻性队列研究纳入了在越南三个大城市的六家医院寻求产前护理的孕妇。入组后，同意参与研究的符合条件的参与者在妊娠24 - 28周时接受访谈。在此期间进行葡萄糖检测并测量血压。每位参与者将在分娩、产后1、3、6、12、18和24个月的产后访视期间接受前瞻性评估，并将随访5年。
在2248名符合条件的孕妇中，2030名在2015年8月至2016年7月期间被招募（参与率90.3%）。所有参与者均完成了基线评估。她们的平均（标准差）年龄为27.6（5.3）岁。孕前平均体重指数（BMI）为20.2（标准差2.6）kg/m²，近三分之二的参与者孕前BMI正常（18.5至<23.0 kg/m²），四分之一体重过轻（孕前BMI<18.5 kg/m²）。超重或肥胖母亲（孕前BMI≥23.0 kg/m²）占12.8%。没有孕妇报告在孕期吸烟，而13.4%的孕妇继续饮酒。22.8%的参与者患有高血糖。她们的平均收缩压为105.6（标准差8.2）mmHg，舒张压为67.4（标准差7.5）mmHg。
将分析孕产妇生活方式和营养状况与妊娠、产后母婴健康结局之间的关系。同时，将密切跟踪参与者以尽量减少失访。
