Lachej Nadežda, Dabkevičienė Daiva, Sasnauskienė Aušra, Trimonytė Rūta Marija, Kanopienė Daiva, Kazbarienė Birutė, Didžiapetrienė Janina
Nacionalinis vėžio institutas, Chemoterapijos skyrius.
Vilniaus universitetas, Gamtos mokslų fakultetas, Biochemijos ir molekulinės biologijos katedra.
Acta Med Litu. 2017;24(1):35-43. doi: 10.6001/actamedica.v24i1.3461.
The body's cell behaviour is controlled by various signalling pathways, one of which is NOTCH. It has been found that a partial loss of the NOTCH function or abnormal strengthening of NOTCH signalling are related to various human diseases and developmental disorders. PubMed was the main source of information for this paper. The paper overviews the association between oncologic diseases and the participants of the NOTCH signalling pathway. In cancerogenesis, the NOTCH signalling pathway can act as a tumour suppressor or an oncogene. The mechanisms of such an effect are yet unknown. The NOTCH signalling pathway is an object of active research because its modulation by pharmacological and genetic approaches could be helpful in discovering new treatment methods of tumours. In this review more attention is paid to gynaecological malignancies, especially to uterine cancer. The findings of recently published studies show that the NOTCH signalling pathway is definitely important for the development of uterine cancer, therefore its components can be potential prognostic biomarkers and molecular therapeutic targets. However, further studies in this field are needed in order to clarify the role of the components of the NOTCH signalling pathway and their interaction with participants of other signalling pathways, which can be important in the development and progression of uterine cancer as well. NOTCH signalling pathway, cancer, gynaecological malignancies.
人体细胞行为受多种信号通路控制，其中之一是NOTCH。研究发现，NOTCH功能部分丧失或NOTCH信号异常增强与多种人类疾病和发育障碍有关。PubMed是本文的主要信息来源。本文综述了肿瘤疾病与NOTCH信号通路相关因素之间的关联。在肿瘤发生过程中，NOTCH信号通路既可以作为肿瘤抑制因子，也可以作为癌基因。这种作用的机制尚不清楚。NOTCH信号通路是当前积极研究的对象，因为通过药理学和遗传学方法对其进行调控可能有助于发现肿瘤的新治疗方法。在本综述中，更多关注的是妇科恶性肿瘤，尤其是子宫癌。最近发表的研究结果表明，NOTCH信号通路对子宫癌的发生发展绝对至关重要，因此其组成成分可能成为潜在的预后生物标志物和分子治疗靶点。然而，为了阐明NOTCH信号通路各组成成分的作用及其与其他信号通路相关因素的相互作用，该领域还需要进一步研究，这些相互作用在子宫癌的发生发展过程中也可能具有重要意义。NOTCH信号通路、癌症、妇科恶性肿瘤。
