巨噬细胞功能随衰老的变化。
Changes in the macrophage function with aging.
作者信息
De La Fuente M
出版信息
Comp Biochem Physiol A Comp Physiol. 1985;81(4):935-8. doi: 10.1016/0300-9629(85)90933-8.
PMID:2863082
Abstract
Changes in the adherence, opsonization, phagocytosis, nitroblue tetrazolium reduction and antibody-dependent cell cytotoxicity of peritoneal macrophages were observed with aging in BALB/C mice. A decrease in all the parameters studied, except for the reduction capacity of nitroblue tetrazolium, which increased with aging, was found in the long-lived mice. The role of the macrophage in immune hyporesponsiveness with aging is discussed.
摘要
观察了BALB/C小鼠随着年龄增长腹膜巨噬细胞在黏附、调理吞噬作用、吞噬作用、硝基蓝四氮唑还原以及抗体依赖性细胞毒性方面的变化。在长寿小鼠中，除硝基蓝四氮唑还原能力随年龄增长而增加外，所研究的所有参数均有所下降。讨论了巨噬细胞在衰老过程中免疫反应低下中的作用。
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