Wrovasc-Integrated Cardiovascular Centre, Provincial Specialized Hospital, Kamieńskiego 73a, 51-124 Wroclaw, Poland.
Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.
Biomed Res Int. 2017;2017:8715909. doi: 10.1155/2017/8715909. Epub 2017 May 29.
The aim of the study was to assess the impact of regular professional sports activity on the endothelial and platelet function in young men. The studied group were 79 young men (18-40 y, 25 athletes and 54 without any regular physical activity). The nitric oxide (NO) metabolic pathway intermediates, oxidative stress markers, mediators of inflammation, and platelet aggregation were measured. Flow mediated dilation (FMD) was studied before and after intravenous 16,0 g L-arginine infusion, which was repeated after oral administration of acetylsalicylic acid (ASA-75 mg/day) for 4 days. Both groups had similar demographic characteristics. In the athletes, there was significantly higher hsCRP level, better serum lipid profile, and lower pulse pressure. Greater baseline FMD in athletes and in response to L-arginine disappeared following ASA treatment. There were no differences in the levels of the NO pathway metabolites. The control group was characterized by higher PAI-1 following ASA treatment and sICAM-1 both at baseline and after ASA, but no differences in MDA and 6-keto-PGF-1 alpha and platelet aggregation were noted. Regular professional physical activity modulates endothelial but not platelet function and may thus exert an effect on overall cardiovascular risk.
本研究旨在评估定期专业体育活动对年轻男性内皮和血小板功能的影响。研究对象为 79 名年轻男性（18-40 岁，25 名运动员和 54 名无任何定期体育活动的人）。测量了一氧化氮（NO）代谢途径的中间产物、氧化应激标志物、炎症介质和血小板聚集。在静脉注射 16.0g L-精氨酸前后研究了血流介导的扩张（FMD），并在连续 4 天每天口服乙酰水杨酸（ASA-75mg）后重复了该研究。两组的人口统计学特征相似。在运动员中，hsCRP 水平显著较高，血脂谱更好，脉搏压更低。在接受 ASA 治疗后，运动员的基础 FMD 和对 L-精氨酸的反应均消失。NO 途径代谢物的水平没有差异。对照组在接受 ASA 治疗后 PAI-1 水平升高，且无论基线水平还是接受 ASA 治疗后 sICAM-1 水平均升高，但 MDA 和 6-酮-PGF-1α以及血小板聚集水平没有差异。定期的专业体育活动可调节内皮功能但不调节血小板功能，从而可能对整体心血管风险产生影响。
