评估二氧化钛纳米颗粒（TiO-NPs）诱导的肝毒性及肉桂对 Sprague-Dawley 大鼠的改善作用。
Assessment of Titanium Dioxide Nanoparticles (TiO-NPs) Induced Hepatotoxicity and Ameliorative Effects of Cinnamomum cassia in Sprague-Dawley Rats.
机构信息
Department of Zoology, Government College University, Faisalabad, Pakistan.
Institute of Pure and Applied Biology, Bahauddin Zakariya University, Multan, Pakistan.
出版信息
Biol Trace Elem Res. 2018 Mar;182(1):57-69. doi: 10.1007/s12011-017-1074-3. Epub 2017 Jun 19.
This study assessed the protective effects of Cinnamomum cassia (cinnamon) bark extract in rats exposed to titanium dioxide nanoparticles or titanium dioxide bulk salt. For in vivo evaluation of the ameliorative role of the cinnamon extract, the experimental groups were orally administered with the cinnamon extract at different dose levels (50 or 100 or 150 mg/kg bodyweight) along with the subcutaneous injections of 150 mg/kg bodyweight titanium dioxide nanoparticles or titanium dioxide bulk salt. The extract showed significant ameliorative role on the antioxidant system in response to elevated levels of titanium dioxide nanoparticles or titanium dioxide bulk salt-induced oxidative stress. It aided in the recovery of the antioxidant system as well as protective role in histological damages and some haematological parameters in the rat liver treated with titanium dioxide nanoparticles or titanium dioxide bulk salt.
本研究评估了肉桂（肉桂）树皮提取物对暴露于二氧化钛纳米粒子或二氧化钛块状盐的大鼠的保护作用。为了评估肉桂提取物的改善作用，实验组通过口服给予不同剂量水平（50 或 100 或 150mg/kg 体重）的肉桂提取物，并同时皮下注射 150mg/kg 体重的二氧化钛纳米粒子或二氧化钛块状盐。提取物对氧化应激反应中二氧化钛纳米粒子或二氧化钛块状盐水平升高的抗氧化系统表现出显著的改善作用。它有助于恢复抗氧化系统，并在大鼠肝脏中对二氧化钛纳米粒子或二氧化钛块状盐处理的组织损伤和一些血液学参数具有保护作用。
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