Mastropasqua Leonardo, Borrelli Enrico, Carpineto Paolo, Toto Lisa, Di Antonio Luca, Mattei Peter A, Mastropasqua Rodolfo
Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, Chieti, Italy.
Moorfields Eye Hospital NHS Foundation Trust, London, UK.
Int Ophthalmol. 2018 Aug;38(4):1465-1472. doi: 10.1007/s10792-017-0608-1. Epub 2017 Jun 19.
To evaluate superficial capillary plexus (SCP) changes occurring after internal limiting membrane (ILM) peeling for the treatment of idiopathic epiretinal membrane (ERM).
A total of 15 eyes of 15 patients affected by idiopathic ERM (eight males and seven females; mean age 59.8 ± 9.6 years) were enrolled in the study. Patients were treated with pars plana vitrectomy followed by ERM and ILM peeling. Subjects were evaluated at baseline and at the week-1 and month-1 follow-up visits. At each visit, patients were evaluated with a complete ophthalmologic evaluation, which included imaging with optical coherence tomography angiography.
Overall, the SCP vessel density was 43.0 ± 3.0% at baseline and was stable throughout the follow-up (40.0 ± 4.0% at week-1 and 41.0 ± 4.0% at month-1 follow-up visits; p = 0.087 and p = 0.426, respectively). Nevertheless, the SCP vessel density was reduced at week-1 visit in both the superior and inferior sectors. In these sectors, the superficial vessel density was still reduced at the month-1 follow-up visit.
We observed a reduction in the SCP vessel density occurring after pars plana vitrectomy with ILM peeling. The reduction is referred to those areas where other changes (e.g., swelling of the arcuate nerve fiber layer) have been already described. In theory, superficial vessel density modifications may be due to the direct surgical trauma to the inner retina, where the superficial plexus is contained, during the ILM grasping.
评估内界膜（ILM）剥除术治疗特发性视网膜前膜（ERM）后浅表毛细血管丛（SCP）的变化。
本研究纳入了15例患有特发性ERM的患者的15只眼（8例男性和7例女性；平均年龄59.8±9.6岁）。患者接受了玻璃体切除术，随后进行ERM和ILM剥除。在基线以及第1周和第1个月的随访时对受试者进行评估。每次随访时，对患者进行全面的眼科评估，包括光学相干断层扫描血管造影成像。
总体而言，SCP血管密度在基线时为43.0±3.0%，在整个随访过程中保持稳定（第1周时为40.0±4.0%，第1个月随访时为41.0±4.0%；p分别为0.087和0.426）。然而，在第1周随访时，上象限和下象限的SCP血管密度均降低。在这些象限中，浅表血管密度在第1个月随访时仍降低。
我们观察到玻璃体切除联合ILM剥除术后SCP血管密度降低。这种降低发生在已经描述了其他变化（如弓形神经纤维层肿胀）的区域。理论上，浅表血管密度的改变可能是由于在抓取ILM过程中对内视网膜（浅表丛所在部位）的直接手术创伤所致。
