Izmir Tepecik Training and Research Hospital Ophthalmology Department, University of Health Sciences, Guney District, Street:1140/1 No:1, Yenisehir-Konak, Izmir, Turkey.
Department of Ophthalmology, Ekol Hospital, Izmir, Turkey.
Int Ophthalmol. 2021 Feb;41(2):621-627. doi: 10.1007/s10792-020-01617-9. Epub 2020 Oct 19.
To evaluate the retinal vascular structure before and after the epiretinal membrane (ERM) surgery by optical coherence tomography angiography (OCTA).
Twenty-two eyes with ERM (study eyes) had been evaluated by OCTA for superficial capillary plexus (SCP) and deep capillary plexus (DCP) vessel density (VD) at foveal and parafoveal regions and foveal avascular zone (FAZ) before and after ERM removal surgery. Twenty-two fellow eyes were selected as control group.
Preoperative VD of SCP and DCP were significantly lower in ERM eyes than in controls in both foveal and parafoveal areas (p < 0.05, for all). The difference regressed in SCP (fovea: 18.04 ± 3.1 vs 19.98 ± 18 p = 0.002 and parafovea: 47.33 ± 3.54 vs 49.71 ± 28 p = 0.001), but persisted in DCP (fovea: 17.25 ± 3.52 vs 17.57 ± 4.01 p = 0.856 and parafovea: 50.12 ± 4.35 vs 50.93 ± 3.24 p = 0.791) in study eyes, postoperatively. Superficial and deep FAZ areas were significantly smaller in study eyes than controls. Postoperatively, superficial FAZ area enlarged (0.288 ± 0.10 vs 0.307 ± 0.08 p = 0.012), whereas deep FAZ area did not (0.324 ± 0.09 vs 0.338 ± 0.07 p = 0.435). FAZ area was correlated with the best-corrected visual acuity in ERM eyes.
Vascular damage in SCP and DCP was demonstrated by OCTA in eyes with ERM. ERM removal surgery mainly improves superficial changes caused by ERM. Changes in deep retinal flow may be associated with visual outcomes after ERM removal surgery.
通过光相干断层扫描血管造影术（OCTA）评估视网膜前膜（ERM）手术后的视网膜血管结构。
对 22 只 ERM 眼（研究眼）进行 OCTA 评估，以评估中心凹和旁中心凹区域浅层毛细血管丛（SCP）和深层毛细血管丛（DCP）血管密度（VD）和中心凹无血管区（FAZ）。选择 22 只对侧眼作为对照组。
术前 ERM 眼的 SCP 和 DCP 在中心凹和旁中心凹区域的 VD 均明显低于对照组（均 p < 0.05）。SCP 中的差异在术后恢复（中心凹：18.04 ± 3.1 对 19.98 ± 18，p = 0.002；旁中心凹：47.33 ± 3.54 对 49.71 ± 28，p = 0.001），而 DCP 中仍存在差异（中心凹：17.25 ± 3.52 对 17.57 ± 4.01，p = 0.856；旁中心凹：50.12 ± 4.35 对 50.93 ± 3.24，p = 0.791）。研究眼的浅层和深层 FAZ 区域明显小于对照组。术后，浅层 FAZ 区域扩大（0.288 ± 0.10 对 0.307 ± 0.08，p = 0.012），而深层 FAZ 区域没有变化（0.324 ± 0.09 对 0.338 ± 0.07，p = 0.435）。FAZ 区域与 ERM 眼的最佳矫正视力相关。
OCTA 显示 ERM 眼中 SCP 和 DCP 存在血管损伤。ERM 去除手术后主要改善由 ERM 引起的浅层变化。深层视网膜血流的变化可能与 ERM 切除术后的视力结果有关。
