脆弱拟杆菌致病岛连接毒力与菌株竞争。
The Bacteroides fragilis pathogenicity island links virulence and strain competition.
作者信息
Casterline Benjamin W, Hecht Aaron L, Choi Vivian M, Bubeck Wardenburg Juliane
机构信息
a Department of Microbiology , University of Chicago , Chicago , IL , USA.
b Interdisciplinary Scientist Training Program , University of Chicago , Chicago , IL , USA.
出版信息
Gut Microbes. 2017 Jul 4;8(4):374-383. doi: 10.1080/19490976.2017.1290758. Epub 2017 Feb 23.
Abstract
The mature microbiome is a stable ecosystem that resists perturbation despite constant host exposure to exogenous microbes. However, the microbial mechanisms determining microbiome development and composition are poorly understood. We recently demonstrated that a non-toxigenic B. fragilis (NTBF) strain restricts enteric colonization by an enterotoxigenic (ETBF) strain dependent on a type VI secretion system (T6SS). We show here that a second enterotoxigenic strain is competent to colonize, dependent on the Bacteroides fragilis pathogenicity island (BFPAI). Additional data showing complex environmental regulation of the Bacteroides fragilis toxin (BFT) suggest that virulence factors may be adapted to modify the colonic niche to provide a strain-specific colonization advantage. We conclude that more complex models of host-microbe-microbiome interactions are needed to investigate this hypothesis.
摘要
成熟的微生物群是一个稳定的生态系统，尽管宿主持续暴露于外源微生物，但它能抵抗扰动。然而，决定微生物群发育和组成的微生物机制仍知之甚少。我们最近证明，一种非产毒素脆弱拟杆菌（NTBF）菌株通过依赖VI型分泌系统（T6SS）的产肠毒素脆弱拟杆菌（ETBF）菌株来限制肠道定植。我们在此表明，第二种产肠毒素菌株能够定植，这依赖于脆弱拟杆菌致病岛（BFPAI）。显示脆弱拟杆菌毒素（BFT）存在复杂环境调控的其他数据表明，毒力因子可能经过适应性改变以修饰结肠生态位，从而提供菌株特异性的定植优势。我们得出结论，需要更复杂的宿主-微生物-微生物群相互作用模型来研究这一假设。
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本文引用的文献
1
Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions.先前的饮食习惯及其与人类肠道微生物元群落的关联会改变对饮食干预的反应。
Cell Host Microbe. 2017 Jan 11;21(1):84-96. doi: 10.1016/j.chom.2016.12.006. Epub 2016 Dec 29.
2
A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility.缺乏膳食纤维的肠道微生物群会破坏结肠黏液屏障并增加对病原体的易感性。
Cell. 2016 Nov 17;167(5):1339-1353.e21. doi: 10.1016/j.cell.2016.10.043.
3
Virulence factors enhance Citrobacter rodentium expansion through aerobic respiration.毒力因子通过有氧呼吸增强啮齿柠檬酸杆菌的增殖。
Science. 2016 Sep 16;353(6305):1249-53. doi: 10.1126/science.aag3042. Epub 2016 Sep 15.
4
Strain competition restricts colonization of an enteric pathogen and prevents colitis.菌株竞争限制肠道病原体的定殖并预防结肠炎。
EMBO Rep. 2016 Sep;17(9):1281-91. doi: 10.15252/embr.201642282. Epub 2016 Jul 18.
5
Temporal Stability of the Human Skin Microbiome.人类皮肤微生物群的时间稳定性
Cell. 2016 May 5;165(4):854-66. doi: 10.1016/j.cell.2016.04.008.
6
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Mucosal Immunol. 2017 Jan;10(1):91-103. doi: 10.1038/mi.2016.45. Epub 2016 May 4.
7
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Immunity. 2015 Nov 17;43(5):909-22. doi: 10.1016/j.immuni.2015.10.008. Epub 2015 Nov 3.
9
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