Bordi C, De Vita O, Pollice L
Hum Pathol. 1985 Sep;16(9):961-4. doi: 10.1016/s0046-8177(85)80139-8.
In a mediastinal teratoma containing pancreatic tissue rich in islet cells, immunofluorescence studies showed a high degree of differentiation of the endocrine tissue. Insulin-, glucagon-, somatostatin-, and pancreatic polypeptide(PP)-containing cells were all consistently represented. They showed the same precise topographic distribution that is seen in normal islets (i.e., a central core of insulin-containing cells with the other cell types in a peripheral position) and that is thought to be important for the integrated function of the islets. This may explain the absence of clinical symptoms of hypoglycemia. In addition, a nonrandom distribution of endocrine cell types, with PP-rich and PP-poor areas, similar to that found in pancreatic regions embryologically derived from the ventral and dorsal anlagen, respectively, was observed. This finding suggests that the unknown mechanisms responsible for the dissimilar endocrine cell contents in pancreatic regions of different embryologic origins were operating in the teratoma.
在一个含有丰富胰岛细胞的胰腺组织的纵隔畸胎瘤中，免疫荧光研究显示内分泌组织有高度分化。含胰岛素、胰高血糖素、生长抑素和胰多肽（PP）的细胞均持续存在。它们呈现出与正常胰岛相同的精确拓扑分布（即含胰岛素细胞位于中央核心，其他细胞类型处于周边位置），并且认为这种分布对胰岛的综合功能很重要。这可能解释了低血糖临床症状的缺失。此外，观察到内分泌细胞类型呈非随机分布，存在富含PP和缺乏PP的区域，类似于分别在胚胎学上源自腹侧和背侧原基的胰腺区域中发现的情况。这一发现表明，在畸胎瘤中，负责不同胚胎起源的胰腺区域内分泌细胞内容物不同的未知机制在起作用。
