Dunn P J
J Clin Pathol. 1984 Oct;37(10):1105-9. doi: 10.1136/jcp.37.10.1105.
Four cases of benign cystic mediastinal teratoma containing pancreatic tissue have been studied using immunohistochemical and morphometric techniques. The different pancreatic endocrine cell types were stained using antibodies to insulin, glucagon, somatostatin, and pancreatic polypeptide, and the volume density of each cell type was estimated by point counting. Sections from different regions of the normal adult pancreas were also examined and the results compared. There was an increased total volume density of endocrine cells in the teratomatous pancreas, with a pronounced increase in the proportion of somatostatin containing D cells. The results are similar to those described for pancreatic tissue in neonates, and it is suggested that this is further evidence of altered functional differentiation of the pancreatic tissue found in teratomas.
我们运用免疫组化和形态计量学技术，对4例含有胰腺组织的良性纵隔囊性畸胎瘤进行了研究。使用抗胰岛素、胰高血糖素、生长抑素和胰多肽的抗体，对不同类型的胰腺内分泌细胞进行染色，并通过点计数法估算每种细胞类型的体积密度。同时也检查了正常成年胰腺不同区域的切片，并将结果进行比较。畸胎瘤性胰腺中内分泌细胞的总体积密度增加，其中含生长抑素的D细胞比例显著增加。这些结果与新生儿胰腺组织的描述相似，提示这进一步证明了畸胎瘤中胰腺组织功能分化的改变。
