Yeh Chao Hsing, Lin Wei-Chun, Kwai-Ping Suen Lorna, Park Na-Jin, Wood Lisa J, van Londen G J, Howard Bovbjerg Dana
School of Nursing, University of Pittsburgh, Pennsylvania.
University of Pittsburgh.
Oncol Nurs Forum. 2017 Jul 1;44(4):476-487. doi: 10.1188/17.ONF.476-487.
PURPOSE/OBJECTIVES: To assess the feasibility of auricular point acupressure to manage aromatase inhibitor-induced arthralgia. .
DESIGN: Wait list control design. .
SETTING: Outpatient clinics and oncology center. .
SAMPLE: 20 women with aromatase inhibitor-induced arthralgia. .
METHODS: After baseline data were collected, participants waited one month before they received acupressure once per week for four weeks at a convenient time. The baseline data served as the control comparison. Self-reported measures and blood samples were obtained at baseline, at preintervention, weekly during the intervention, and at post-intervention. .
MAIN RESEARCH VARIABLES: The primary outcomes included pain intensity, pain interference, stiffness, and physical function. Inflammatory cytokines and chemokines were tested. .
FINDINGS: After the four-week intervention, participants reported decreases in worst pain and pain interference, and improvements in physical function, cancer-related symptom severity, and interference. The proinflammatory cytokines and chemokines displayed a trend of a mean percentage reduction. The anti-inflammatory cytokine interleukin-13 increased from pre- to postintervention. .
CONCLUSIONS: Auricular point acupressure is feasible and may be effective in managing arthralgia in breast cancer survivors. .
Nurses can administer acupressure in clinical settings, which could enhance the management of aromatase inhibitor-induced arthralgia and contribute to a shift from traditional disease-based biomedical models to a broader, integrative, medical paradigm for managing aromatase inhibitor-induced arthralgia.
目的/目标：评估耳穴按压法用于治疗芳香化酶抑制剂所致关节痛的可行性。
等候名单对照设计。
门诊诊所和肿瘤中心。
20名患有芳香化酶抑制剂所致关节痛的女性。
收集基线数据后，参与者等待1个月，然后在方便的时间每周接受1次耳穴按压，共4周。基线数据用作对照比较。在基线、干预前、干预期间每周以及干预后获取自我报告的测量数据和血样。
主要结局包括疼痛强度、疼痛干扰、僵硬程度和身体功能。对炎性细胞因子和趋化因子进行检测。
经过4周干预后，参与者报告最严重疼痛和疼痛干扰减轻，身体功能、癌症相关症状严重程度及干扰情况有所改善。促炎细胞因子和趋化因子显示出平均百分比降低的趋势。抗炎细胞因子白细胞介素-13在干预后较干预前有所增加。
耳穴按压法可行，可能对乳腺癌幸存者的关节痛有治疗效果。
护士可在临床环境中实施耳穴按压法，这有助于加强对芳香化酶抑制剂所致关节痛的管理，并推动从传统的基于疾病的生物医学模式向更广泛的、综合的医学模式转变，以管理芳香化酶抑制剂所致关节痛。
