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耳穴按压法治疗绝经后乳腺癌幸存者芳香化酶抑制剂所致关节痛的一项初步研究

Auricular Point Acupressure to Manage Aromatase Inhibitor-Induced Arthralgia in Postmenopausal Breast Cancer Survivors: A Pilot Study.

作者信息

Yeh Chao Hsing, Lin Wei-Chun, Kwai-Ping Suen Lorna, Park Na-Jin, Wood Lisa J, van Londen G J, Howard Bovbjerg Dana

机构信息

School of Nursing, University of Pittsburgh, Pennsylvania.

University of Pittsburgh.

出版信息

Oncol Nurs Forum. 2017 Jul 1;44(4):476-487. doi: 10.1188/17.ONF.476-487.

Abstract

PURPOSE/OBJECTIVES: To assess the feasibility of auricular point acupressure to manage aromatase inhibitor-induced arthralgia.
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DESIGN: Wait list control design.
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SETTING: Outpatient clinics and oncology center.
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SAMPLE: 20 women with aromatase inhibitor-induced arthralgia.
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METHODS: After baseline data were collected, participants waited one month before they received acupressure once per week for four weeks at a convenient time. The baseline data served as the control comparison. Self-reported measures and blood samples were obtained at baseline, at preintervention, weekly during the intervention, and at post-intervention.
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MAIN RESEARCH VARIABLES: The primary outcomes included pain intensity, pain interference, stiffness, and physical function. Inflammatory cytokines and chemokines were tested.
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FINDINGS: After the four-week intervention, participants reported decreases in worst pain and pain interference, and improvements in physical function, cancer-related symptom severity, and interference. The proinflammatory cytokines and chemokines displayed a trend of a mean percentage reduction. The anti-inflammatory cytokine interleukin-13 increased from pre- to postintervention.
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CONCLUSIONS: Auricular point acupressure is feasible and may be effective in managing arthralgia in breast cancer survivors.
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IMPLICATIONS FOR NURSING

Nurses can administer acupressure in clinical settings, which could enhance the management of aromatase inhibitor-induced arthralgia and contribute to a shift from traditional disease-based biomedical models to a broader, integrative, medical paradigm for managing aromatase inhibitor-induced arthralgia.

摘要

目的/目标:评估耳穴按压法用于治疗芳香化酶抑制剂所致关节痛的可行性。

设计

等候名单对照设计。

地点

门诊诊所和肿瘤中心。

样本

20名患有芳香化酶抑制剂所致关节痛的女性。

方法

收集基线数据后,参与者等待1个月,然后在方便的时间每周接受1次耳穴按压,共4周。基线数据用作对照比较。在基线、干预前、干预期间每周以及干预后获取自我报告的测量数据和血样。

主要研究变量

主要结局包括疼痛强度、疼痛干扰、僵硬程度和身体功能。对炎性细胞因子和趋化因子进行检测。

研究结果

经过4周干预后,参与者报告最严重疼痛和疼痛干扰减轻,身体功能、癌症相关症状严重程度及干扰情况有所改善。促炎细胞因子和趋化因子显示出平均百分比降低的趋势。抗炎细胞因子白细胞介素-13在干预后较干预前有所增加。

结论

耳穴按压法可行,可能对乳腺癌幸存者的关节痛有治疗效果。

对护理工作的启示

护士可在临床环境中实施耳穴按压法,这有助于加强对芳香化酶抑制剂所致关节痛的管理,并推动从传统的基于疾病的生物医学模式向更广泛的、综合的医学模式转变,以管理芳香化酶抑制剂所致关节痛。

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