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细胞大小:脂肪使细胞肥胖。

Cell Size: Fat Makes Cells Fat.

机构信息

Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Sainsbury Laboratory, Cambridge University, Cambridge CB2 1LR, UK.

Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

出版信息

Curr Biol. 2017 Jun 19;27(12):R592-R594. doi: 10.1016/j.cub.2017.05.017.

DOI:10.1016/j.cub.2017.05.017
PMID:28633027
Abstract

Nutrients are required for the multiple biosynthetic pathways that result in cell growth, and faster growth due to increased nutrient supply results in larger cell volume. A new study demonstrates that fatty-acid availability limits growth rate and cell envelope capacity, revealing that fatty-acid synthesis is the primary determinant of cell size in bacteria and in budding yeast.

摘要

营养物质是多种生物合成途径所必需的,这些途径导致细胞生长,而由于营养物质供应增加导致的更快生长导致细胞体积增大。一项新的研究表明,脂肪酸的可用性限制了生长速度和细胞包膜容量,揭示了脂肪酸合成是细菌和出芽酵母中细胞大小的主要决定因素。

相似文献

1
Cell Size: Fat Makes Cells Fat.细胞大小:脂肪使细胞肥胖。
Curr Biol. 2017 Jun 19;27(12):R592-R594. doi: 10.1016/j.cub.2017.05.017.
2
Fatty acid uptake and blood flow in adipose tissue compartments of morbidly obese subjects with or without type 2 diabetes: effects of bariatric surgery.伴有或不伴有2型糖尿病的病态肥胖受试者脂肪组织区域的脂肪酸摄取和血流:减肥手术的影响
Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E175-E182. doi: 10.1152/ajpendo.00044.2017. Epub 2017 Apr 11.
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Brown adipose tissue lipid metabolism in morbid obesity: Effect of bariatric surgery-induced weight loss.病态肥胖患者棕色脂肪组织的脂质代谢:减重手术的影响。
Diabetes Obes Metab. 2018 May;20(5):1280-1288. doi: 10.1111/dom.13233. Epub 2018 Feb 22.
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Tissue specific regulation of glucocorticoids in severe obesity and the response to significant weight loss following bariatric surgery (BARICORT).严重肥胖中糖皮质激素的组织特异性调节以及减肥手术后显著体重减轻的反应(BARICORT)
J Clin Endocrinol Metab. 2015 Apr;100(4):1434-44. doi: 10.1210/jc.2014-4120. Epub 2015 Jan 20.
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Effect of bariatric surgery on liver glucose metabolism in morbidly obese diabetic and non-diabetic patients.肥胖症糖尿病患者与非糖尿病患者行减重手术后对肝脏葡萄糖代谢的影响。
J Hepatol. 2014 Feb;60(2):377-83. doi: 10.1016/j.jhep.2013.09.012. Epub 2013 Sep 20.
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Differential loss of fat and lean mass in the morbidly obese after bariatric surgery.病态肥胖患者接受减重手术后体脂和去脂体重的差异丢失。
Metab Syndr Relat Disord. 2010 Feb;8(1):15-20. doi: 10.1089/met.2009.0012.
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Hepatic and visceral adipose tissue 11βHSD1 expressions are markers of body weight loss after bariatric surgery.肝脏和内脏脂肪组织 11βHSD1 的表达是减重手术后体重下降的标志物。
Obesity (Silver Spring). 2015 Sep;23(9):1856-63. doi: 10.1002/oby.21173. Epub 2015 Aug 4.
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Whey Protein Supplementation Enhances Body Fat and Weight Loss in Women Long After Bariatric Surgery: a Randomized Controlled Trial.乳清蛋白补充剂可在减肥手术后很长一段时间内促进女性身体脂肪减少和体重减轻:一项随机对照试验。
Obes Surg. 2017 Feb;27(2):424-431. doi: 10.1007/s11695-016-2308-8.
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Fatty Acid Availability Sets Cell Envelope Capacity and Dictates Microbial Cell Size.脂肪酸可用性决定了细胞包膜的容量,并决定了微生物细胞的大小。
Curr Biol. 2017 Jun 19;27(12):1757-1767.e5. doi: 10.1016/j.cub.2017.05.076. Epub 2017 Jun 8.
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[Preoperative weight loss in bariatric surgery candidate patients. evidence-based recommendations].[肥胖症手术候选患者的术前体重减轻。循证推荐意见]
Cir Esp. 2012 Mar;90(3):147-55. doi: 10.1016/j.ciresp.2011.10.020. Epub 2012 Jan 16.

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