Costa M D, Baszkin A
J Pharm Pharmacol. 1985 Jul;37(7):455-60. doi: 10.1111/j.2042-7158.1985.tb03039.x.
The surface free energies (gamma SV) of the integral and partial tablet formulations of an antiarrhythmic drug--cibenzoline succinate, have been assessed by contact angle measurements using high-viscosity polyols and Neumann's equation of state. Independent measurements of penetration for these liquids into the tablets yielded pore size values through the use of the Washburn equation. The role of different constituents of the formulations are analysed in terms of their influence upon the free surface energy of the tablets and penetration rates. The relation between (gamma SV) and penetration rates yields for a series of liquids two threshold values: (gamma SV)s 'start' and (gamma SV)r, 'rapid', which define respectively the beginning of the measurable penetration and the rapid penetration.
通过使用高粘度多元醇的接触角测量和诺伊曼状态方程，评估了抗心律失常药物琥珀酸西苯唑啉的完整片剂配方和部分片剂配方的表面自由能（γSV）。通过使用沃什伯恩方程，对这些液体渗入片剂的情况进行独立测量，得出了孔径值。从配方中不同成分对片剂自由表面能和渗透速率的影响方面，分析了它们的作用。对于一系列液体，γSV与渗透速率之间的关系产生了两个阈值：（γSV）s“开始”和（γSV）r“快速”，它们分别定义了可测量渗透的开始和快速渗透。
