Buckton G, Newton J M
J Pharm Pharmacol. 1986 May;38(5):329-34. doi: 10.1111/j.2042-7158.1986.tb04582.x.
The use of a liquid penetration technique to assess the wettability and surface energy of a series of barbiturates, including the use of bicomponent systems, has been critically evaluated. Values of apparent contact angles (theta) obtained using the Washburn relationship (1921) and the Carli & Simioni correction (1979) were found to reflect the practically derived wettability of the powders. Values of gamma c obtained from modified Zisman plots and from Neumann's equation of state did not realistically describe the surface energies of the powders. The nature of alcohol-water mixtures has been examined to assist elucidation of the theoretical problems associated with the technique and to offer a possible explanation for the inadequacies of the surface energy results.
已经对使用液体渗透技术评估一系列巴比妥类药物的润湿性和表面能进行了严格评估，包括使用双组分系统。使用沃什伯恩关系（1921年）和卡利与西米奥尼校正（1979年）获得的表观接触角（θ）值被发现反映了粉末实际得出的润湿性。从修正的齐斯曼图和诺伊曼状态方程获得的γc值并未真实地描述粉末的表面能。已经研究了酒精 - 水混合物的性质，以帮助阐明与该技术相关的理论问题，并为表面能结果的不足之处提供可能的解释。
