葡萄糖脱氢酶3D打印葡萄糖传感器的研发：一项概念验证研究。
The Development of a Glucose Dehydrogenase 3D-Printed Glucose Sensor: A Proof-of-Concept Study.
作者信息
Adams Anngela, Malkoc Aldin, La Belle Jeffrey T
机构信息
1 School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA.
2 School of Medicine, Mayo Clinic Arizona, Scottsdale, AZ, USA.
出版信息
J Diabetes Sci Technol. 2018 Jan;12(1):176-182. doi: 10.1177/1932296817715272. Epub 2017 Jun 21.
Abstract
This work represents a preliminary proof-of-concept design and verification of a 3D-printed glucose biosensor. The proof of concept presented is the first example of glucose dehydrogenase sensor fabricated by a 3D-printer while maintaining similar features to current lab-industry standards. The sensor was verified to detect physiological glucose concentrations between 0 and 400 mg/dL with a linear coefficient as high as .97. This study showed that it was possible to use 3D-printed technology to create a biosensor sensitive to glucose detection. As availability and functionality of 3D-printers expands, this technology has the potential to be an option for diabetes management. This preliminary study shows that the 3D-printed sensor platform holds promise for sensitive glucose detection.
摘要
这项工作代表了一种3D打印葡萄糖生物传感器的初步概念验证设计与验证。所展示的概念验证是由3D打印机制造的葡萄糖脱氢酶传感器的首个实例，同时保持了与当前实验室-行业标准相似的特性。该传感器经验证可检测0至400mg/dL的生理葡萄糖浓度，线性系数高达0.97。这项研究表明，利用3D打印技术制造对葡萄糖检测敏感的生物传感器是可行的。随着3D打印机的可用性和功能不断扩展，这项技术有可能成为糖尿病管理的一种选择。这项初步研究表明，3D打印传感器平台在灵敏葡萄糖检测方面具有前景。
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