Hathaway Hollie, Milo Scarlet, Sutton J Mark, Jenkins Toby A
Department of Chemistry, University of Bath, Bath BA2 7AY, UK.
Technology Development Group, Public Health England, Porton Down, SP4 0JG, UK.
Ther Deliv. 2017 Jul;8(7):543-556. doi: 10.4155/tde-2017-0040.
Antibiotics have been the cornerstone of clinical management of bacterial infection since their discovery in the early 20th century. However, their widespread and often indiscriminate use has now led to reports of multidrug resistance becoming globally commonplace. Bacteriophage therapy has undergone a recent revival in battle against pathogenic bacteria, as the self-replicating and co-evolutionary features of these predatory virions offer several advantages over conventional therapeutic agents. In particular, the use of targeted bacteriophage therapy from specialized delivery platforms has shown particular promise owing to the control of delivery location, administration conditions and dosage of the therapeutic cargo. This review presents an overview of the recent formulations and applications of such delivery vehicles as an innovative and elegant tool for bacterial control.
自20世纪初发现抗生素以来，它们一直是细菌感染临床治疗的基石。然而，它们的广泛使用且常常是不加区分的使用，如今已导致多重耐药的报道在全球变得司空见惯。噬菌体疗法最近在对抗病原菌的斗争中再度兴起，因为这些掠食性病毒粒子的自我复制和共同进化特性相对于传统治疗剂具有若干优势。特别是，来自专门递送平台的靶向噬菌体疗法由于对治疗性药物的递送位置、给药条件和剂量的控制而显示出特别的前景。本综述概述了此类递送载体的最新制剂和应用，作为一种用于细菌控制的创新且精巧的工具。
