Arnold Nichelle, Manway Mitch, Stephenson Sean, Lipkin Howard
Michigan State University Dermatology Residency Program, Beaumont Hospital Farmington Hills, Farmington Hills, Michigan.
Dermatol Online J. 2017 Jun 15;23(6):13030/qt8dn3p7kv.
Lichen sclerosus (LS) is a benign, chronic, inflammatory skin disease with a predilection for the anogenital region in women. Although males can also be affected, the ratio of female to male incidence has been reported to be as high as 6-10:1 and possesses a bimodal age distribution of pre-pubertal girls and postmenopausal women [1, 2]. Affected skin usually demonstrates polygonal papules that coalesce into porcelain white plaques and can be associated with edema, telangiectasias, and comedo-like plug formation [3]. Lichen sclerosus can be debilitating for some patients causing significant pruritus, pain, dysuria, and dyspareunia [4]. Rarely, lichen sclerosus appears in various extragenital areas, although most cases are relatively asymptomatic [3]. Even more uncommonly, as displayed in this case report of a 69-year-old woman, LS can present extragenitally with a bullous or hemorrhagic appearance [5].
硬化性苔藓(LS)是一种良性、慢性炎症性皮肤病,好发于女性的肛门生殖器区域。虽然男性也可受累,但据报道女性与男性的发病率之比高达6 - 10:1,且具有青春期前女孩和绝经后女性两个发病高峰的年龄分布[1, 2]。受累皮肤通常表现为多边形丘疹,融合成瓷白色斑块,并可伴有水肿、毛细血管扩张和粉刺样栓子形成[3]。硬化性苔藓可使一些患者衰弱,导致严重瘙痒、疼痛、排尿困难和性交困难[4]。虽然大多数病例相对无症状,但硬化性苔藓很少出现在各种生殖器外区域[3]。更罕见的是,如本病例报告中的一名69岁女性所示,硬化性苔藓可在生殖器外表现为大疱性或出血性外观[5]。