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出血性大疱性硬化性苔藓:病例报告

Hemorrhagic Bullous Lichen Sclerosus: A Case Report.

作者信息

Khatib Jude, Wargo Jeffrey J, Krishnamurthy Smita, Travers Jeffrey B

机构信息

Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA.

Department of Dermatology, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA.

出版信息

Am J Case Rep. 2020 Oct 7;21:e919353. doi: 10.12659/AJCR.919353.

Abstract

BACKGROUND Lichen sclerosus (LS) is a chronic autoimmune dermatosis characterized by white, sclerotic, atrophic plaques. Classic LS commonly occurs in the anogenital region, while extragenital lichen sclerosis typically occurs on the trunk and proximal extremities. Bullous lichen sclerosus is a rare variant that can occur in both genital and extragenital LS. Flaccid bullae can form, which may become hemorrhagic and produce a characteristic appearance clinically. CASE REPORT In this report, we describe the case of a 63-year-old female patient who presented for evaluation of a rapidly growing, erythematous, scaly growth on her back/shoulder that was biopsied and found to be hemorrhagic bullous LS. We will discuss the clinical and histologic features of this case as well as treatment of bullous LS, which in this case was a topical high-potency corticosteroid. CONCLUSIONS Bullous LS has been poorly studied due to the rarity of the condition, with limited investigation of the clinical and histopathologic characteristics of bullous LS and the available treatment options. Although rare, extragenital LS with hemorrhagic bullous features is an important variant of LS that should be considered to ensure appropriate diagnosis and treatment.

摘要

背景 硬化性苔藓(LS)是一种慢性自身免疫性皮肤病,其特征为白色、硬化性、萎缩性斑块。经典的LS通常发生于肛门生殖器区域,而生殖器外硬化性苔藓则典型地发生于躯干和四肢近端。大疱性硬化性苔藓是一种罕见的变异型,可发生于生殖器和生殖器外的LS。可形成松弛性大疱,临床上可出现出血并呈现特征性外观。病例报告 在本报告中,我们描述了一名63岁女性患者的病例,该患者因背部/肩部迅速生长的红斑鳞屑性肿物前来评估,活检发现为出血性大疱性LS。我们将讨论该病例的临床和组织学特征以及大疱性LS的治疗,本病例采用的是外用强效糖皮质激素治疗。结论 由于大疱性LS病例罕见,对其临床和组织病理学特征以及现有治疗选择的研究有限。虽然罕见,但具有出血性大疱特征的生殖器外LS是LS的一种重要变异型,应予以考虑以确保正确的诊断和治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/360f/7552941/f2daaad7e427/amjcaserep-21-e919353-g001.jpg

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