Key Laboratory Medical Molecular Virology, MoE/MoH, and the Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, People's Republic of China.
Key Laboratory Medical Molecular Virology, MoE/MoH, and the Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, People's Republic of China; Shanghai Minhang Center for Diseases Control and Prevention, Shanghai, 201101, People's Republic of China.
J Infect. 2017 Sep;75(3):216-224. doi: 10.1016/j.jinf.2017.06.004. Epub 2017 Jun 17.
To understand the epidemiology and disease burden of norovirus (NoVs) gastroenteritis in China, a systematic review was conducted.
Studies on acute gastroenteritis (AGE) caused by NoVs from mainland China, published before 2017 were searched. All retrieved articles were screened and reviewed by a standardized algorithm. NoVs detection rates as well as strain variations by ages, seasonal variations and geographic locations were analyzed using random-effects model.
A total of 225 articles were included in the final analysis. Similar detection rates at 21.0% and 19.8% were obtained from the North and the South, respectively. NoVs infection occurred year round, with a peak between October and January in the North and between August and November in the South. High detection rates (∼29%) of NoVs were found in adults and the elderly and in children aged 6-35 months (∼22%). The predominant strains were GII.4 (70.4%), followed by GII.3 (13.5%).
NoVs cause significant disease burden in China which warrants development of vaccines against NoVs, particularly for children and the elderly who are vulnerable to gastroenteritis diseases. To achieve a broad protection, continual monitoring NoV epidemics and strain variations for selection of proper vaccine strains is critical.
为了了解中国诺如病毒（NoV）胃肠炎的流行病学和疾病负担，我们进行了一项系统评价。
检索了中国大陆诺如病毒引起的急性胃肠炎（AGE）的研究，检索时间截至 2017 年以前。所有检索到的文章均采用标准化算法进行筛选和审查。采用随机效应模型分析了不同年龄、季节和地理位置的 NoV 检出率和毒株变化情况。
共有 225 篇文章被纳入最终分析。北方和南方的检出率分别为 21.0%和 19.8%，较为相似。NoV 感染全年均可发生，北方的高峰期在 10 月至 1 月，南方在 8 月至 11 月。成人和老年人以及 6-35 个月的儿童（约 22%）的 NoV 检出率较高（约 29%）。主要流行株为 GII.4（70.4%），其次为 GII.3（13.5%）。
NoV 在我国造成了巨大的疾病负担，因此有必要开发针对 NoV 的疫苗，特别是针对易患胃肠炎疾病的儿童和老年人。为了实现广泛的保护，持续监测 NoV 流行情况和毒株变化对于选择合适的疫苗株至关重要。
