Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Key Laboratory of Agricultural Microbiomics and Precision Application, Ministry of Agriculture and Rural Affairs, Guangzhou, Guangdong, 510070, China; College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, 510632, China.
Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Key Laboratory of Agricultural Microbiomics and Precision Application, Ministry of Agriculture and Rural Affairs, Guangzhou, Guangdong, 510070, China.
Food Microbiol. 2023 Feb;109:104140. doi: 10.1016/j.fm.2022.104140. Epub 2022 Sep 10.
Human noroviruses (HuNoVs) have been found as the leading cause of acute gastroenteritis outbreaks in all age groups and are significantly correlated with the consumption of shellfish. In this study, the contamination of HuNoVs in shellfish was estimated through a systematic review and meta-analysis. Studies on the contamination of HuNoVs in shellfish were searched from PubMed, Web of Science, Embase, and Cochrane Library from January 2000 to August 2021. A total of 75 studies were included, and the pooled HuNoVs prevalence in shellfish was 29% (95% CI: 23-35) worldwide. As revealed by the results of the subgroup meta-analysis, the prevalence of dominant genogroup was variable, and 4% (95% CI: 3-6), 13% (95% CI: 10-17), with 7% (95% CI: 4-11) of the samples, respectively, contaminated by GI alone, GII alone, and GI&GII. The HuNoVs prevalence of shellfish in Europe, America, and Asia was 33% (95% CI: 24-43), 24% (95% CI: 7-47), and 27% (95% CI: 18-35), respectively, while only 10% (95% CI: 5-17) in Africa. Furthermore, the prevalence of HuNoVs in shellfish was the highest in spring (35%, 95% CI: 23-49) and winter (35%, 95% CI: 22-50), and the lowest in summer (11%, 95% CI: 5-18). Oysters, clams, and mussels had comparable HuNoVs prevalence of 28% (95% CI: 20-37), 27% (95% CI: 16-39) and 24% (95% CI: 17-32), respectively. The prevalence of HuNoVs in shellfish from harvest areas and markets was 30% (95% CI: 23-38) and 30% (95% CI: 19-41), respectively. The results of this study suggest a substantial burden of HuNoVs in shellfish worldwide, with GII.4 (92.86%) and GII.2 (46.43%) as the predominant genotypes. This study provides information regarding the contamination of HuNoVs in shellfish worldwide, which will contribute to the development of appropriate control measures to prevent shellfish-related HuNoVs gastroenteritis.
人类诺如病毒（HuNoVs）已被发现是所有年龄段急性胃肠炎暴发的主要原因，并且与贝类的食用显著相关。在本研究中，通过系统评价和荟萃分析来估计贝类中 HuNoVs 的污染情况。从 2000 年 1 月至 2021 年 8 月，从 PubMed、Web of Science、Embase 和 Cochrane Library 中搜索了关于贝类中 HuNoVs 污染的研究。共纳入 75 项研究，全球贝类中 HuNoVs 的总流行率为 29%（95%CI：23-35）。亚组荟萃分析的结果显示，优势基因型的流行率各不相同，分别有 4%（95%CI：3-6）、13%（95%CI：10-17）和 7%（95%CI：4-11）的样本被 GI 型、GII 型和 GI&GII 型单独污染。欧洲、美洲和亚洲贝类中 HuNoVs 的流行率分别为 33%（95%CI：24-43）、24%（95%CI：7-47）和 27%（95%CI：18-35），而非洲仅为 10%（95%CI：5-17）。此外，贝类中 HuNoVs 的流行率在春季（35%，95%CI：23-49）和冬季（35%，95%CI：22-50）最高，在夏季（11%，95%CI：5-18）最低。牡蛎、蛤和贻贝的 HuNoVs 流行率分别为 28%（95%CI：20-37）、27%（95%CI：16-39）和 24%（95%CI：17-32）。收获区和市场贝类的 HuNoVs 流行率分别为 30%（95%CI：23-38）和 30%（95%CI：19-41）。本研究结果表明，全球贝类中 HuNoVs 存在较大负担，以 GII.4（92.86%）和 GII.2（46.43%）为主要基因型。本研究提供了全球贝类中 HuNoVs 污染的相关信息，这将有助于制定适当的控制措施来预防与贝类相关的 HuNoVs 胃肠炎。
