Wang Dan, Wang Ming-Liang, Li Yue-Hua
Institute of Diagnostic and Interventional Radiology, The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University, 600 Yi Shan Road, Shanghai 200233, China.
Institute of Diagnostic and Interventional Radiology, The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University, 600 Yi Shan Road, Shanghai 200233, China.
Brain Res. 2017 Aug 15;1669:126-130. doi: 10.1016/j.brainres.2017.06.016. Epub 2017 Jun 19.
To use Ktrans to evaluate the aggressiveness and vascular permeability of peritumoral edema in cases of lung cancer brain metastases.
A total of 68 lung cancer patients with 92 metastatic brain lesions were enrolled (20 metastatic lesions only in the gray matter - group 1; and 72 metastatic lesions located in the gray and white matter junction - group 2). All patients underwent MRI examination, which involved a dual angle (2° and 15°) enhanced T1W-VIBE (volume interpolated breath-hold examination) sequence to calculate the T1 parameter map. We used the enhanced T1-3D sequence to measure the tumor volume. The vascular permeability coefficient (Ktrans) was calculated using the single-compartment Tofts model, motion registration, and quick input mode. We examined the correlations of Ktrans with the edema index (EI), Ktrans with the tumor volume, and Ktrans with the histological expression of MMP-9 or VEGF in the original lung tumor using Pearson's' correlation analysis.
Ktrans and EI were highly correlated in group 2 (r=0.66687; P<0.001) and not correlated in group 1 (r=0.33096; P=0.15405). Ktrans was also moderately related to the positive expression of MMP-9 (r=0.50912; P<0.001) and VEGF (r=0.36995; P=0.00138) There is statistical correlation between Ktrans and EI for group 2, and no statistical correlation between Ktrans and EI for group 1.
The Ktrans of the peritumoral brain edema may be used to indicate the aggressiveness and vascular permeability of brain metastases in patients with lung cancer.
运用转运常数（Ktrans）评估肺癌脑转移患者瘤周水肿的侵袭性和血管通透性。
共纳入68例肺癌患者，其脑内有92处转移灶（仅20处转移灶位于灰质 - 第1组；72处转移灶位于灰白质交界区 - 第2组）。所有患者均接受了MRI检查，检查采用双角度（2°和15°）增强T1加权容积内插屏气检查（VIBE）序列以计算T1参数图。我们使用增强T1-3D序列测量肿瘤体积。采用单室Tofts模型、运动配准和快速输入模式计算血管通透性系数（Ktrans）。我们采用Pearson相关分析研究Ktrans与水肿指数（EI）的相关性、Ktrans与肿瘤体积的相关性以及Ktrans与原发肺肿瘤中基质金属蛋白酶-9（MMP-9）或血管内皮生长因子（VEGF）组织学表达的相关性。
第2组中Ktrans与EI高度相关（r = 0.66687；P < 0.001），而第1组中两者不相关（r = 0.33096；P = 0.15405）。Ktrans与MMP-9的阳性表达（r = 0.50912；P < 0.001）以及VEGF（r = 0.36995；P = 0.00138）也呈中度相关。第2组中Ktrans与EI存在统计学相关性，第1组中Ktrans与EI无统计学相关性。
肺癌患者瘤周脑水肿的Ktrans可用于指示脑转移灶的侵袭性和血管通透性。
