白蛋白在肝硬化中的作用：从一名住院医师的视角
Role of albumin in cirrhosis: from a hospitalist's perspective.
作者信息
Walayat Saqib, Martin Daniel, Patel Jaymon, Ahmed Umair, N Asghar Muhammad, Pai Aparna U, Dhillon Sonu
机构信息
Department of Internal Medicine, University of Illinois Peoria Campus, OSF Saint Francis Medical Center, Peoria, IL, USA.
Department of Gastroenterology and Hepatology, University of Illinois Peoria Campus, OSF Saint Francis Medical Center, Peoria, IL, USA.
出版信息
J Community Hosp Intern Med Perspect. 2017 Mar 31;7(1):8-14. doi: 10.1080/20009666.2017.1302704. eCollection 2017 Jan.
Abstract
Albumin, a negatively charged globular protein encoded on chromosome 4, is one of the most abundant proteins in the plasma and accounts for approximately 75% of plasma oncotic pressure. The role of albumin in the management of various disease states has shown to be beneficial historically. Low serum albumin is a predictor of mortality and poor outcomes. In cirrhotics undergoing paracentesis, albumin infusion prevents rapid re-accumulation of ascitic fluid while simultaneously decreasing the risk of post-paracentesis related circulatory dysfunction. Additionally, albumin is utilized in patients with hepatorenal syndrome (HRS) and spontaneous bacterial peritonitis (SBP). Overall, albumin appears to be an effective pharmacological agent in the management of cirrhosis and its complications.
摘要
白蛋白是一种由4号染色体编码的带负电荷的球状蛋白，是血浆中含量最丰富的蛋白质之一，约占血浆胶体渗透压的75%。从历史上看，白蛋白在各种疾病状态的管理中所起的作用已被证明是有益的。低血清白蛋白是死亡率和不良预后的一个预测指标。在接受腹腔穿刺术的肝硬化患者中，输注白蛋白可防止腹水迅速重新积聚，同时降低腹腔穿刺术后相关循环功能障碍的风险。此外，白蛋白还用于肝肾综合征（HRS）和自发性细菌性腹膜炎（SBP）患者。总体而言，白蛋白似乎是治疗肝硬化及其并发症的一种有效药物。
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