Ali Sajid, Kanjwal Yousuf, Bruhl Steven R, Alo Mohammed, Taleb Mohammed, Ali Syed S, Kabour Ameer, Khawaja Owais
Department of Cardiovascular Medicine, Mercy St. Vincent Hospital and Medical Center, Toledo, OH, USA.
Ther Adv Infect Dis. 2017 May;4(3):75-82. doi: 10.1177/2049936117702317. Epub 2017 May 1.
Cardiac implantable electronic device (CIED) infection has been a major clinical problem in addition to being a major financial burden. In spite of antimicrobial prophylaxis, CIED infection rates have been increasing disproportionately. We therefore conducted this meta-analysis to assess the role of TYRX antibiotic envelope for the prevention of CIED infection.
Using extensive online search, we conducted a meta-analysis of studies reporting CIED infections with without the use of TYRX antibiotic envelope. A random-effect model was used, and between studies heterogeneity was estimated with I. All analyses were performed with RevMan (version 5.0.20).
Five cohort studies were included in this meta-analysis. The pooled odds ratio (OR) of included studies was 0.29 [95% confidence interval (CI): 0.09-0.94; < 0.004]. There was evidence of heterogeneity with I of 58%. There was also evidence of publication bias on funnel plot analysis. On sensitivity analysis, no statistically significant difference was noted when stratified by study design or duration of follow-up.
The results of our study demonstrate a significant beneficial effect of TYRX antibiotic envelope for the prevention of CIED infections.
心脏植入式电子设备（CIED）感染一直是一个重大临床问题，同时也是一项重大经济负担。尽管采取了抗菌预防措施，但CIED感染率仍在不成比例地上升。因此，我们进行了这项荟萃分析，以评估TYRX抗生素包膜在预防CIED感染中的作用。
通过广泛的在线搜索，我们对报告使用或未使用TYRX抗生素包膜的CIED感染的研究进行了荟萃分析。采用随机效应模型，并使用I²估计研究间的异质性。所有分析均使用RevMan（版本5.0.20）进行。
本荟萃分析纳入了五项队列研究。纳入研究的合并比值比（OR）为0.29[95%置信区间（CI）：0.09 - 0.94；P < 0.004]。有证据表明异质性为I² = 58%。漏斗图分析也有发表偏倚的证据。在敏感性分析中，按研究设计或随访时间分层时未发现统计学显著差异。
我们的研究结果表明TYRX抗生素包膜在预防CIED感染方面具有显著的有益效果。
