Kumar Ashish, Doshi Rajkumar, Shariff Mariam
Department of Critical Care Medicine St John's Medical College Hospital Bangalore India.
Department of Internal Medicine University of Nevada Reno School of Medicine Reno NV USA.
J Arrhythm. 2019 Nov 18;36(1):176-179. doi: 10.1002/joa3.12262. eCollection 2020 Feb.
We conducted an updated meta-analysis assessing the role of antibiotic envelopes in preventing Cardiac implantable electronic devices (CIED)-related infections as compared to standard infection prevention strategies.
A systematic search was conducted on Medline/PubMed and EMBASE/Ovid database. We used Mantel-Haenszel method with fixed-effect model to compute risk ratio (RR) with 95% confidence interval (CI). We also performed subgroup and trial sequential analysis on the data.
Antibiotic envelope reduced the risk of both all infections [RR: 0.41, CI: 0.31-0.54, < .05, = 75%, < .05] and major infections [RR: 0.48, CI: 0.32-0.70, < .05, = 60%, = .04].
Prophylactic use of antibiotic envelopes as an adjuvant therapy to standard infection prevention strategies, helps in reducing the risk of CIED infections.
我们进行了一项更新的荟萃分析，评估与标准感染预防策略相比，抗生素包膜在预防心脏植入式电子设备（CIED）相关感染中的作用。
对Medline/PubMed和EMBASE/Ovid数据库进行系统检索。我们使用固定效应模型的Mantel-Haenszel方法计算风险比（RR）及95%置信区间（CI）。我们还对数据进行了亚组分析和试验序贯分析。
抗生素包膜降低了所有感染的风险[RR：0.41，CI：0.31 - 0.54，P <.05，I² = 75%，P <.05]和主要感染的风险[RR：0.48，CI：0.32 - 0.70，P <.05，I² = 60%，P =. .04]。
预防性使用抗生素包膜作为标准感染预防策略的辅助治疗，有助于降低CIED感染的风险。
