Department of Emergency, Beijing Aerospace General Hospital, Beijing, China.
Department of Neurosurgery, Sanbo Brain Hospital of Eleven Clinical College of Capital Medical University, Beijing, China.
Neurol Sci. 2017 Sep;38(9):1629-1636. doi: 10.1007/s10072-017-3020-8. Epub 2017 Jun 21.
This study aimed to quantify whether there is association between music-based movement therapy and motor dysfunction in patients with Parkinson's disease, and, if so, whether music-based movement therapy can be used as first-line non-pharmacological treatment. To conduct a systematic review and meta-analysis of clinical trials that examined the effect of music-based movement therapy on patient-relevant and disease-specific outcomes. Comprehensive literature was searched of PubMed, EMbase, and the Cochrane Library from inception to November 2016. Randomized controlled trial of patients with Parkinson's disease was searched to identify trials comparing music-based movement therapy with no music care. A total of 8 studies (11 analyses, 241 subjects) were included; all of them had acceptable quality by PEDro scale score. Studies based on any type of Parkinson's disease patients were combined and subgroup analyzed. Compared with the control group, the SMD of Berg Balance Scale score was 0.85(0.46 to 1.25), -0.60 (-0.98 to -0.22) in Parkinson Disease Questionnaire-39 summary index, -0.90s (-1.56 to -0.23) in Time Up and Go text, and -0.43 (-1.11 to 0.25) in Unified Parkinson's Disease Rating Scale Motor Subscale 3 as instrument methods for motor function. Secondary outcomes included cognitive function and quality of life. There was positive evidence to support the use of music-based movement therapy on treatment of motor function; there was neutral evidence to support the use of music for the treatment of cognitive function quality of life.
本研究旨在量化音乐运动疗法与帕金森病患者运动功能障碍之间的相关性，如果存在相关性，音乐运动疗法是否可以作为一线非药物治疗方法。对从开始到 2016 年 11 月期间在 PubMed、EMbase 和 Cochrane Library 上进行的临床试验进行系统评价和荟萃分析，以考察音乐运动疗法对患者相关和疾病特异性结局的影响。对所有纳入的研究进行了偏倚风险评估，使用 CMA 软件进行荟萃分析。共纳入 8 项研究（11 项分析，241 例患者），所有研究均通过 PEDro 量表评分达到了可接受的质量标准。将基于任何类型帕金森病患者的研究进行合并，并进行亚组分析。与对照组相比，Berg 平衡量表评分的标准化均数差（SMD）为 0.85（0.46 至 1.25），帕金森病问卷-39 综合指数为-0.60（-0.98 至-0.22），计时起立行走测试时间为-0.90s（-1.56 至-0.23），统一帕金森病评定量表运动评分（UPDRS-Motor）为-0.43（-1.11 至 0.25）。作为运动功能的仪器测量方法。次要结局包括认知功能和生活质量。有阳性证据支持音乐运动疗法对运动功能的治疗作用；有中性证据支持音乐对认知功能和生活质量的治疗作用。
