Di Sieno Laura, Boetti Nadia G, Dalla Mora Alberto, Pugliese Diego, Farina Andrea, Konugolu Venkata Sekar Sanathana, Ceci-Ginistrelli Edoardo, Janner Davide, Pifferi Antonio, Milanese Daniel
Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milano, Italy.
Istituto Superiore Mario Boella, Via P. C. Boggio 61, 10138, Torino, Italy.
J Biophotonics. 2018 Jan;11(1). doi: 10.1002/jbio.201600275. Epub 2017 Jun 21.
In the last years bioresorbable materials are gaining increasing interest for building implantable optical components for medical devices. In this work we show the fabrication of bioresorbable optical fibers designed for diffuse optics applications, featuring large core diameter (up to 200 μm) and numerical aperture (0.17) to maximize the collection efficiency of diffused light. We demonstrate the suitability of bioresorbable fibers for time-domain diffuse optical spectroscopy firstly checking the intrinsic performances of the setup by acquiring the instrument response function. We then validate on phantoms the use of bioresorbable fibers by applying the MEDPHOT protocol to assess the performance of the system in measuring optical properties (namely, absorption and scattering coefficients) of homogeneous media. Further, we show an ex-vivo validation on a chicken breast by measuring the absorption and scattering spectra in the 500-1100 nm range using interstitially inserted bioresorbable fibers. This work represents a step toward a new way to look inside the body using optical fibers that can be implanted in patients. These fibers could be useful either for diagnostic (e. g. for monitoring the evolution after surgical interventions) or treatment (e. g. photodynamic therapy) purposes. Picture: Microscopy image of the 100 μm core bioresorbable fiber.
近年来，生物可吸收材料在制造用于医疗设备的可植入光学组件方面越来越受到关注。在这项工作中，我们展示了用于漫射光学应用的生物可吸收光纤的制造，其特点是具有大芯径（高达200μm）和数值孔径（0.17），以最大限度地提高漫射光的收集效率。我们首先通过获取仪器响应函数来检查装置的固有性能，从而证明生物可吸收光纤适用于时域漫射光学光谱。然后，我们通过应用MEDPHOT协议在体模上验证生物可吸收光纤的使用，以评估系统在测量均匀介质光学特性（即吸收系数和散射系数）方面的性能。此外，我们通过使用间质插入的生物可吸收光纤测量500 - 1100nm范围内的吸收光谱和散射光谱，在鸡胸上进行了离体验证。这项工作代表了朝着使用可植入患者体内的光纤观察人体内部的新方法迈出的一步。这些光纤可用于诊断（例如监测手术干预后的进展）或治疗（例如光动力疗法）目的。图：100μm芯生物可吸收光纤的显微镜图像。
