用于生物光子学应用的漫射光学固态体模配方：迈向解剖学正确的三维组织体模的一步。
Solid phantom recipe for diffuse optics in biophotonics applications: a step towards anatomically correct 3D tissue phantoms.
作者信息
Sekar Sanathana Konugolu Venkata, Pacheco Andrea, Martella Pierluigi, Li Haiyang, Lanka Pranav, Pifferi Antonio, Andersson-Engels Stefan
机构信息
Biophotonics@Tyndall, IPIC, Tyndall National Institute, Lee Maltings, Dyke Parade, Cork, Ireland.
Department of Physics, University College Cork, College Road, Cork, T12 K8AF, Ireland.
出版信息
Biomed Opt Express. 2019 Mar 28;10(4):2090-2100. doi: 10.1364/BOE.10.002090. eCollection 2019 Apr 1.
We present a tissue mimicking optical phantom recipe to create robust well tested solid phantoms. The recipe consists of black silicone pigment (absorber), silica microspheres (scatterer) and silicone rubber (SiliGlass, bulk material). The phantom recipe was characterized over a broadband spectrum (600-1100 nm) for a wide range of optical properties (absorption 0.1-1 cm, reduced scattering 5-25 cm) that are relevant to human organs. The results of linearity show a proper scaling of optical properties as well as the absence of coupling between the absorber and scatterer at different concentrations. A reproducibility of 4% among different preparations was obtained, with a similar grade of spatial homogeneity. Finally, a 3D non-scattering mock-up phantom of an infant torso made with the same recipe bulk material (SiliGlass) was presented to project the futuristic aspect of our work that is 3D printing human organs of biomedical relevance.
我们提出了一种组织模拟光学体模配方，以创建经过充分测试的坚固固体体模。该配方由黑色硅酮颜料（吸收剂）、二氧化硅微球（散射剂）和硅橡胶（SiliGlass，基体材料）组成。该体模配方在宽光谱范围（600 - 1100 nm）内针对与人体器官相关的广泛光学特性（吸收系数0.1 - 1 cm，约化散射系数5 - 25 cm）进行了表征。线性度结果表明光学特性具有适当的比例关系，并且在不同浓度下吸收剂和散射剂之间不存在耦合。不同制备之间的重现性为4%，空间均匀性等级相似。最后，展示了一个用相同配方基体材料（SiliGlass）制作的婴儿躯干三维无散射模型体模，以展现我们工作的未来发展方向，即3D打印具有生物医学相关性的人体器官。
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