Department of Nutritional Sciences, University of Texas at Austin, Austin, Texas, USA.
Department of Medicine, Columbia University Medical Center, New York, New York, USA.
Matern Child Nutr. 2018 Jan;14(1). doi: 10.1111/mcn.12481. Epub 2017 Jun 21.
The authors examined the relationship of prepregnancy body mass index (BMI) and gestational weight gain (GWG) with child neurodevelopment. Mother-child dyads were a subgroup (n = 2,084) of the Child Health and Development Studies from the Oakland, California, area enrolled during pregnancy from 1959 to 1966 and followed at child age 9 years. Linear regression was used to examine associations between prepregnancy BMI, GWG, and standardized Peabody Picture Vocabulary Test and Raven Progressive Matrices scores and to evaluate effect modification of GWG by prepregnancy BMI. Before pregnancy, 77% of women were normal weight, 8% were underweight, 11% were overweight, and 3% were obese. Associations between GWG and child outcomes did not vary by prepregnancy BMI, suggesting no evidence for interaction. In multivariable models, compared to normal prepregnancy BMI, prepregnancy overweight and obesity were associated with lower Peabody scores (b: -1.29; 95% CI [-2.6, -0.04] and b: -2.7; 95% CI [-5.0, -0.32], respectively). GWG was not associated with child Peabody score [b: -0.03 (95% CI: -0.13, 0.07)]. Maternal BMI and GWG were not associated with child Raven score (all P >0.05). Maternal prepregnancy overweight and obesity were associated with lower scores for verbal recognition in mid-childhood. These results contribute to evidence linking maternal BMI with child neurodevelopment. Future research should examine the role of higher prepregnancy BMI values and the pattern of pregnancy weight gain in child cognitive outcomes.
作者研究了孕前体重指数（BMI）和孕期体重增加（GWG）与儿童神经发育的关系。在奥克兰（加利福尼亚州）地区进行的儿童健康与发育研究中，选取了孕期在 1959 年至 1966 年期间入组的母婴对子（n=2084）作为亚组，并在儿童 9 岁时进行随访。采用线性回归来检验孕前 BMI、GWG 与标准化 Peabody 图片词汇测验和 Raven 渐进矩阵测验分数之间的关系，并评估 GWG 对孕前 BMI 的效应修饰。在怀孕前，77%的女性体重正常，8%的女性体重不足，11%的女性超重，3%的女性肥胖。GWG 与儿童结局之间的关联与孕前 BMI 无关，提示没有交互作用的证据。在多变量模型中，与正常的孕前 BMI 相比，孕前超重和肥胖与较低的 Peabody 分数相关（b：-1.29；95%CI[-2.6，-0.04]和 b：-2.7；95%CI[-5.0，-0.32]）。GWG 与儿童 Peabody 分数无关（b：-0.03；95%CI[-0.13，0.07]）。母亲 BMI 和 GWG 与儿童 Raven 分数无关（所有 P>0.05）。母亲孕前超重和肥胖与儿童中期的语言识别能力下降有关。这些结果为将母亲 BMI 与儿童神经发育联系起来的证据提供了补充。未来的研究应探讨更高的孕前 BMI 值和妊娠体重增加模式在儿童认知结果中的作用。
