Russell Melissa A, Janson Christer, Real Francisco Gómez, Johannessen Ane, Waatevik Marie, Benediktsdóttir Bryndis, Holm Mathias, Lindberg Eva, Schlünssen Vivi, Raza Wasif, Dharmage Shyamali C, Svanes Cecilie
a Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health , University of Melbourne , Melbourne , Australia.
b Gastro & Food Allergy Group , Murdoch Children's Research Institute , Melbourne , Australia.
J Asthma. 2017 Nov;54(9):938-945. doi: 10.1080/02770903.2017.1281293. Epub 2017 Feb 16.
To investigate the impact of physical activity on asthma in middle-aged adults, in one longitudinal analysis, and one multi-centre cross-sectional analysis.
The Respiratory Health in Northern Europe (RHINE) is a population-based postal questionnaire cohort study. Physical activity, height and weight were self-reported in Bergen, Norway, at RHINE II (1999-2001) and all centres at RHINE III (2010-2012). A longitudinal analysis of Bergen data investigated the association of baseline physical activity with follow-up asthma, incident asthma and symptoms, using logistic and zero-inflated Poisson regression (n = 1782). A cross-sectional analysis of all RHINE III centres investigated the association of physical activity with concurrent asthma and symptoms (n = 13,542) using mixed-effects models. Body mass index (BMI) was categorised (<20, 20-24.99, 25-29.99, 30+ kg/m) and physical activity grouped by amount and frequency of lighter (no sweating/heavy breathing) and vigorous (sweating/heavy breathing) activity.
In the Bergen longitudinal analysis, undertaking light activity 3+ times/week at baseline was associated with less follow-up asthma (odds ratio [OR] 0.44, 95% confidence interval [CI] 0.22, 0.89), whilst an effect from undertaking vigorous activity 3+ times/week was not detected (OR 1.22, 95% CI 0.44, 2.76). The associations were attenuated with BMI adjustment. In the all-centre cross-sectional analysis an interaction was found, with the association between physical activity and asthma varying across BMI categories.
These findings suggest potential longer-term benefit from lighter physical activity, whilst improvement in asthma outcomes from increasing activity intensity was not evident. Additionally, it appears the benefit from physical activity may differ according to BMI.
在一项纵向分析和一项多中心横断面分析中，研究身体活动对中年成年人哮喘的影响。
北欧呼吸健康（RHINE）研究是一项基于人群的邮寄问卷调查队列研究。在挪威卑尔根的RHINE II（1999 - 2001年）以及RHINE III所有中心（2010 - 2012年），通过自我报告获取身体活动、身高和体重信息。对卑尔根的数据进行纵向分析，使用逻辑回归和零膨胀泊松回归研究基线身体活动与随访哮喘、新发哮喘及症状之间的关联（n = 1782）。对所有RHINE III中心的数据进行横断面分析，使用混合效应模型研究身体活动与同期哮喘及症状之间的关联（n = 13542）。体重指数（BMI）分为<20、20 - 24.99、25 - 29.99、30+ kg/m²，身体活动根据轻度（无出汗/重度呼吸）和剧烈（出汗/重度呼吸）活动的量和频率进行分组。
在卑尔根纵向分析中，基线时每周进行3次以上轻度活动与随访时哮喘较少相关（优势比[OR] 0.44，95%置信区间[CI] 0.22，0.89），而未检测到每周进行3次以上剧烈活动的影响（OR 1.22，95% CI 0.44，2.76）。经BMI调整后，这些关联减弱。在所有中心横断面分析中发现了一种交互作用，身体活动与哮喘之间在不同BMI类别中的关联有所不同。
这些发现表明轻度身体活动可能具有潜在的长期益处，而增加活动强度对哮喘结局的改善并不明显。此外，身体活动的益处似乎可能因BMI而异。
