Dipartimento di Biologia e Biotecnologie Università degli Studi di Pavia, Via Ferrata, 1. I-27100 Pavia, Italy.
Istituto Geriatrico P. Redaelli -Reparti di Riabilitazione Geriatrica e di Mantenimento, Via Leopardi, 3. I-20090 Vimodrone, Milano, Italy.
Nutrients. 2017 Jun 21;9(6):637. doi: 10.3390/nu9060637.
Essential amino acids (EAAs) are nutritional substrates that promote body protein synthesis; thus we hypothesised that their supplementation may improve circulating albumin (Alb) and haemoglobin (Hb) in rehabilitative elderly patients following hip fractures (HF). Out of the 145 HF patients originally enrolled in our study, 112 completed the protocol. These subjects were divided into two randomised groups, each containing 56 patients. For a period of two months, one group (age 81.4 ± 8.1 years; male/female 27/29) received a placebo, and the other (age 83.1 ± 7.5 years; male/female 25/31) received 4 + 4 g/day oral EAAs. At admission, the prevalence of both hypoAlb (<3.5 g/dL) and hypoHb (<13 g/dL male, <12 g/dL female) was similar in the placebo group (64.3% hypoAlb, 66% hypoHb) and the treated group of patients (73.2% hypoAlb, 67.8% hypoHb). At discharge, however, the prevalence of hypoAlb had reduced more in EAAs than in placebo subjects (31.7% in EAAs vs. 77.8% in placebo; < 0.001). There was a 34.2% reduction of anaemia in hypoHb in EAA subjects and 18.9% in placebo subjects, but the difference was not statistically significant. Oral supplementation of EAAs improves hypoAlb and, to a lesser extent, Hb in elderly rehabilitative subjects with hip fractures. Anaemia was reduced in more than one third of patients, which, despite not being statistically significant, may be clinically relevant.
必需氨基酸（EAA）是促进身体蛋白质合成的营养底物；因此，我们假设它们的补充可能会改善髋部骨折（HF）后康复老年患者的循环白蛋白（Alb）和血红蛋白（Hb）。在最初纳入我们研究的 145 名 HF 患者中，有 112 名完成了方案。这些患者被分为两组，每组 56 名患者。在两个月的时间里，一组（年龄 81.4 ± 8.1 岁；男/女 27/29）接受安慰剂，另一组（年龄 83.1 ± 7.5 岁；男/女 25/31）接受 4 + 4 g/天口服 EAA。入院时，安慰剂组（64.3% Alb 低，66% Hb 低）和治疗组患者（73.2% Alb 低，67.8% Hb 低）的 Alb 和 Hb 低值的患病率相似。然而，出院时，EAA 组的 Alb 低值患病率下降幅度大于安慰剂组（EAA 组 31.7%，安慰剂组 77.8%；<0.001）。EAA 组的 Hb 低值贫血减少了 34.2%，安慰剂组减少了 18.9%，但差异无统计学意义。口服 EAA 补充可改善髋部骨折康复老年患者的 Alb 低值，并且在较小程度上改善 Hb 低值。贫血减少了三分之一以上的患者，尽管没有统计学意义，但可能具有临床意义。
