Dipartimento di Biologia e Biotecnologie Università degli Studi di Pavia, Via Ferrata, 1, 27100, Pavia, Italy.
Istituto Geriatrico P. Redaelli -Reparti di Riabilitazione Geriatrica e di Mantenimento, Via Leopardi, 3, 20090, Vimodrone, Milano, Italy.
Aging Clin Exp Res. 2019 Jan;31(1):157-160. doi: 10.1007/s40520-018-0941-x. Epub 2018 Apr 17.
The purpose of this study was to investigate whether supplemented essential amino acids (EAAs) could enhance rehabilitation therapy (Rehab) for recovery of walking capacity in subjects after hip fracture surgery (HFS). Eighty-three elderly subjects with HFS (20 ± 11 days after acute trauma) were eligible for the study and randomized to receive Rehab only (Rehab; n = 27), Rehab + placebo (RP; n = 28) or Rehab + EAAs (RE 8 g/day; n = 28). The patients' walking capacity (m) was measured by 6-min walking distance (6MWD) at admission and at discharge (median 66 days after admission). All patient groups were treated with the same Rehab (2 sessions/day × 5 days/week). The results showed that the gain in 6MWD was higher in RE than in Rehab and RP (p = 0.034; p = 0.024). The study shows that EAA supplementation can enhance walking recovery rate in subjects with HFS.
本研究旨在探讨补充必需氨基酸（EAA）是否可以增强髋关节骨折手术后（HFS）患者的康复治疗（Rehab）以恢复行走能力。83 名患有 HFS 的老年患者（急性创伤后 20±11 天）符合研究条件，并随机分为仅接受 Rehab（Rehab；n=27）、Rehab+安慰剂（RP；n=28）或 Rehab+EAA（RE 8g/天；n=28）治疗。患者的步行能力（m）通过入院时和出院时的 6 分钟步行距离（6MWD）测量（入院后中位数 66 天）。所有患者组均接受相同的 Rehab（每天 2 次/×每周 5 天）治疗。结果表明，RE 组的 6MWD 增加量高于 Rehab 和 RP 组（p=0.034；p=0.024）。该研究表明，EAA 补充可以提高 HFS 患者的步行恢复速度。
