Isaacson P G, O'Connor N T, Spencer J, Bevan D H, Connolly C E, Kirkham N, Pollock D J, Wainscoat J S, Stein H, Mason D Y
Lancet. 1985 Sep 28;2(8457):688-91. doi: 10.1016/s0140-6736(85)92930-7.
Malignant lymphoma complicating coeliac disease has been characterised on morphological and immunocytochemical grounds as malignant histiocytosis of the intestine (MHI). Fresh tissue from four cases of MHI was studied by means of a panel of monoclonal antibodies; in three cases tumour DNA was studied for immunoglobulin and T-cell receptor (TCR) gene rearrangement. Immunocytochemistry showed a T-cell phenotype in all four cases, confirmed by the demonstration of a rearranged TCR beta-chain gene in the three cases studied. Lymphoma complicating coeliac disease thus appears to be of T-cell, rather than histiocyte, origin.
并发腹腔疾病的恶性淋巴瘤在形态学和免疫细胞化学基础上被界定为肠道恶性组织细胞增生症（MHI）。应用一组单克隆抗体对4例MHI的新鲜组织进行了研究；对其中3例肿瘤DNA进行了免疫球蛋白和T细胞受体（TCR）基因重排研究。免疫细胞化学显示所有4例均为T细胞表型，所研究的3例中TCRβ链基因重排证实了这一点。因此，并发腹腔疾病的淋巴瘤似乎起源于T细胞，而非组织细胞。
